Table 2

Number of up- or down-regulated genes in the discordant twins with MS compared to their healthy siblings.

Number of twin pairs


1/8*

2/8**

3/8


Up-regulated

194

25

6

Down-regulated

111

15

0

Total no of genes with change

305

38

6


Genes with at least two-fold change are included.

The proportion of up-regulated genes was significantly higher compared to the proportion of down-regulated genes within twin pair groups *p = 0.023; **p = 0.01 in X-2 test.

Särkijärvi et al. BMC Medical Genetics 2006 7:11   doi:10.1186/1471-2350-7-11

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