Table 1

Frequency and disease risk of 5 classes of genotypes under the model.

Class

Susceptible homozygotes

Heterozygote of susceptible alleles

Heterozygote with one R and one S allele

Heterozygote of resistant alleles

Resistant homozygotes


Genotype

SiSi

SiSi, i j

RiSj

RiRj, i j

RiRi

Frequency

Θ

q2 - Θ

2 pq

p2 - Π

Π

Probability of Favorable Outcome

x

ax

bx

cx

dx


Notation: Frequency of allele Si is qi; frequency of allele Ri is pi. p = pi; q = qi = 1 - p; ; . The subscripts of R alleles and the subscripts of the S alleles are unrelated.

Lipsitch et al. BMC Medical Genetics 2003 4:2   doi:10.1186/1471-2350-4-2

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