Table 1

Frequency and disease risk of 5 classes of genotypes under the model.

Class

Susceptible homozygotes

Heterozygote of susceptible alleles

Heterozygote with one R and one S allele

Heterozygote of resistant alleles

Resistant homozygotes

Genotype

S_iS_i

S_iS_i, i ≠ j

R_iS_j

R_iR_j, i ≠ j

R_iR_i

Frequency

Θ

q² - Θ

2 pq

p² - Π

Π

Probability of Favorable Outcome

x

ax

bx

cx

dx

Notation: Frequency of allele S_i is q_i; frequency of allele R_i is p_i. p = p_i; q = q_i = 1 - p; ; . The subscripts of R alleles and the subscripts of the S alleles are unrelated.

Lipsitch et al. BMC Medical Genetics 2003 4:2   doi:10.1186/1471-2350-4-2