Resolution:
## Figure 1.
Population heterozygote advantage as a function of allele-specific effects and allele
frequencies. Parameter regions in which heterozygotes will on average have a higher probability
of a favorable disease outcome than homozygotes (regions of population heterozygote
advantage) are shown in black. Population heterozygote advantage occurs when diversity
of resistant alleles is sufficiently high and diversity of susceptible alleles is
sufficiently low i.e., toward the bottom right of the parameter space in each panel
of the figure. Different panels indicate various assumptions about the genotype-specific
relative risks a-d (defined in Table 1). Parameters: Overdominant (a = 1.1, b = 1.6, c = 2, d = 1.5); dominant (a = 1, b = c = d); additive (a = 1, b = (1 + c)/2, c = d); recessive (a = b = 1, c = d); underdominant (a = 0.5, b = 0.9, c = 1.4, d = 1.5). These curves are drawn for p = 0.5. Dominant, additive and recessive curves are valid for all possible values of
the free parameters, while underdominant and overdominant curves are examples whose
positions depend on the particular values of the parameters a, b, c and d.
Lipsitch |