|
CHEK2*1100delC in breast cancer cases and healthy controls |
|
| Positive for CHEK2*1100delC (%) |
|
|
|
|
| Controls |
|
| Jewish (New York) |
3/1096 (0.3%) |
| Non-Jewish (New York) |
2/569 (0.4%) |
| Total |
5/1665 (0.3%) |
| BRCA1/2-negative individuals of mixed ethnicity with breast cancer from families with 3 or more cases of breast cancer |
0/67 (0.0%) |
| BRCA1/2 Ashkenazi founder mutation-negative individuals with breast cancer from families with 3 or more cases of breast cancer |
1/33# (3.0%) |
| BRCA2-negativei individuals of mixed ethnicity with male breast cancer |
0/16 (0.0%) |
| Individuals with bilateral breast cancer of mixed ethnicity unselected for family history |
0/46 (0.0%) |
| Individuals with unilateral breast cancer unselected for family history matched for age, ethnicity |
1/46 (2.2%) |
| Clinic-ascertained individuals of Ashkenazi Jewish descent with bilateral breast cancer |
1/46 (2.2%) |
| Clinic-ascertained individuals of Ashkenazi Jewish descent with unilateral breast cancer matched for age, family history |
0/46 (0.0%) |
|
#This case previously reported in CHEK2 Breast Cancer Consortium [5]. | |
Offit et al. BMC Medical Genetics 2003 4:1 doi:10.1186/1471-2350-4-1 |
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