Table 3

Associations of CAPN10 haplotypes with type 2 diabetes in urban Ghana
Haplotypea Genotype N Controls Type 2 diabetes OR (95% CI) P aOR (95% CI)b P
111 n 1048 374 674
- - 608 219 (58.6) 389 (57.7) Reference
111 - 376 140 (37.4) 236 (35.0)
111 111 64 15 (4.0) 49 (7.3) 1.12 (0.91–1.38) 0.30 1.00 (0.75–1.34) 0.98
Frequency 0.23 0.25
112 n 1048 374 674
- - 224 82 (21.9) 142 (21.1) Reference
112 - 544 183 (48.9) 361 (53.6)
112 112 280 109 (29.1) 171 (25.4) 0.94 (0.78–1.13) 0.51 0.95 (0.74–1.22) 0.67
Frequency 0.54 0.52
121 n 1048 374 674
- - 823 296 (79.1) 527 (78.2) Reference
121 - 205 72 (19.3) 133 (19.7)
121 121 20 6 (1.6) 14 (2.1) 1.07 (0.81–1.40) 0.64 1.40 (0.99–1.99) 0.06
Frequency 0.11 0.12
122 n 1048 374 674
- - 1039 372 (99.5) 667 (99.0) Reference
122 - 9 2 (0.5) 7 (1.0)
122 122 0 0 (0.0) 0 (0.0) 1.95 (0.40–9.44) 0.41 3.87 (0.61–24.52) 0.15
Frequency 0.01 0.01
221 n 1048 374 674
- - 853 298 (79.7) 555 (82.3) Reference
221 - 186 72 (19.3) 114 (16.9)
221 221 9 4 (1.1) 5 (0.7) 0.84 (0.63–1.14) 0.27 0.73 (0.48–1.10) 0.13
Frequency 0.11 0.09
211 n 1048 374 674
- - 1041 369 (98.7) 672 (99.7) Reference
211 - 7 5 (1.3) 2 (0.3)
211 211 0 0 (0.0) 0 (0.0) 0.22 (0.04–1.14) 0.07 0.32 (0.03–2.92) 0.31
Frequency 0.01 0.001
212 n 1048 374 674
- - 1043 372 (99.5) 671 (99.6) Reference
212 - 5 2 (0.5) 3 (0.4)
212 212 0 0 (0.0) 0 (0.0) 0.83 (0.14–5.00) 0.84 - /
Frequency 0.003 0.002
222 N 1048 374 674
- - 1030 370 (98.9) 660 (97.9) Reference
222 - 18 4 (1.2) 14 (2.1)
222 222 0 0 (0.0) 0 (0.0) 1.96 (0.64–6.00) 0.24 1.20 (0.28–5.04) 0.81
Frequency 0.01 0.01

a, Haplotypes were constructed from genotype data using the software package PHASE version 2.1 [23,24].

b, Adjusted for age, gender, BMI ≥25.0 kg/m2 and hypertension status.

Danquah et al.

Danquah et al. BMC Medical Genetics 2013 14:96   doi:10.1186/1471-2350-14-96

Open Data