Table 1

Estimated haplotype distributions for selected D-amino acid oxidase (DAO), protein phosphatise 3 catalytic subunit gamma isoform (PPP3CCC) and dystrobrevin-binding protein 1 (DTNBP1) single nucleotide polymorphisms in patients with schizophrenia and control subjects and in females and males samples
DAO Haplotype (rs2070586|rs3741775)
Haplotype Patientsa Controlsb χ2 DF P P correctc
Total samples N = 386 N = 476
GG 0.42 0.40 0.69 1 0.41
AT 0.21 0.19 1.40 1 0.24
GT 0.37 0.41 3.70 1 0.05 0.13
Females N = 126 N = 270
GG 0.43 0.39 1.31 1 0.25
AT 0.23 0.17 3.88 1 0.05 0.11
GT 0.33 0.44 8.65 1 0.003 0.009
Males N = 260 N = 206
GG 0.41 0.41 0.01 1 0.92
AT 0.20 0.21 0.10 1 0.75
GT 0.39 0.38 0.03 1 0.86
PPP3CC Haplotype (rs4872499|rs11780915|rs13271367)
Haplotype Patientsa Controlsb χ2 DF P P correctc
Total samples N = 383 N = 476
CGA 0.61 0.56 3.50 1 0.06
TAG 0.22 0.21 0.62 1 0.43
CAG 0.13 0.19 11.56 1 7x10-4 0.001
others 0.03 0.03
Females N = 125 N = 269
CGA 0.60 0.57 0.63 1 0.43
TAG 0.22 0.17 2.65 1 0.10
CAG 0.12 0.20 7.60 1 0.006 0.04
others 0.05 0.05
Males N = 258 N = 207
CGA 0.61 0.55 3.52 1 0.06
TAG 0.22 0.25 1.14 1 0.29
CAG 0.13 0.17 2.98 1 0.08
others 0.03 0.02
DTNBP1 Haplotype (rs6459409|rs9476886)
Total samples N = 381 N = 473
CT 0.17 0.20 2.18 1 0.14
TT 0.13 0.12 0.78 1 0.38
TC 0.69 0.68 0.28 1 0.60
Females N = 125 N = 270
CT 0.20 0.17 0.62 1 0.43
TT 0.15 0.12 1.23 1 0.27
TC 0.65 0.70 1.84 1 0.17
Males N = 256 N = 203
CT 0.16 0.24 8.55 1 0.003 0.006
TT 0.12 0.11 0.34 1 0.56
TC 0.71 0.65 3.77 1 0.05 0.14

ahaplotype frequencies in schizophrenia patients.

bhaplotype frequencies in control subjects.

DF = degree of freedom.

cPcorrect after 10000 permutations.

Sacchetti et al.

Sacchetti et al. BMC Medical Genetics 2013 14:33   doi:10.1186/1471-2350-14-33

Open Data