Open Access Research article

Schizophrenia susceptibility and NMDA-receptor mediated signalling: an association study involving 32 tagSNPs of DAO, DAOA, PPP3CC, and DTNBP1 genes

Emilio Sacchetti123, Catia Scassellati4, Alessandra Minelli5, Paolo Valsecchi12, Cristian Bonvicini4, Patrizio Pasqualetti6, Alessandro Galluzzo12, Rosaria Pioli7 and Massimo Gennarelli45*

Author Affiliations

1 Psychiatric Unit, University of Brescia, School of Medicine, Viale Europa 11, Brescia, 25123, Italy

2 Department of Mental Health, Brescia Spedali Civili, Brescia, Italy

3 Center of Behavioral and Neurodegenerative Disorders, Brescia University and EULO, Brescia, Italy

4 Genetic Unit, I.R.C.C.S. “San Giovanni di Dio” – Fatebenefratelli, Via Pilastroni 4, Brescia, 25125, Italy

5 Department of Molecular and Translational Medicine, Division of Biology and Genetics, Viale Europa 11, Brescia, 25123, Italy

6 AFaR, Department of Neuroscience, Hospital Fatebenefratelli Isola Tiberina, Rome, 00186, Italy

7 Psychitric Unit, I.R.C.C.S. “San Giovanni di Dio” - Fatebenefratelli, Brescia, Italy

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BMC Medical Genetics 2013, 14:33  doi:10.1186/1471-2350-14-33

Published: 9 March 2013

Additional files

Additional file 1: Table S1:

Allele and genotype association analyses for single SNPs in D-amino acid oxidase, DAO, D-amino acid oxidase activator, DAOA, protein phosphatase 3 catalytic subunit gamma isoform, PPP3CC and dystrobrevin-binding protein 1, DTNBP1 genes. Table S2. The linkage disequilibrium (LD) block structures of the D-amino acid oxidase, DAO (A); D-amino acid oxidase activator, DAOA (B); protein phosphatase 3 catalytic subunit gamma isoform, PPP3CC (C); and dystrobrevin-binding protein 1, DTNBP1 (D) genes for the cases and controls. Table S3. Significant results from the secondary analyses for D-amino acid oxidase, DAO; protein phosphatase 3 catalytic subunit gamma isoform, PPP3CC. A. Interaction effect of DAO GT diplotype and PPP3CC CAG triplotype carriers. B. Multinomial logistic regression analyses in DAO GT diplotype and PPP3CC CAG triplotype carriers in paranoid/non paranoid sample.

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