Open Access Highly Accessed Research article

Risk loci for coronary artery calcification replicated at 9p21 and 6q24 in the Heinz Nixdorf Recall Study

Sonali Pechlivanis1*, Thomas W Mühleisen23, Stefan Möhlenkamp4, Dirk Schadendorf5, Raimund Erbel4, Karl-Heinz Jöckel1, Per Hoffmann23, Markus M Nöthen23, André Scherag1, Susanne Moebus1 and for the Heinz Nixdorf Recall Study Investigative Group

Author Affiliations

1 Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany

2 Institute of Human Genetics, University of Bonn, Bonn, Germany

3 Department of Genomics, Life & Brain GmbH, University of Bonn, Bonn, Germany

4 Clinic of Cardiology, West-German Heart Centre, University Hospital Essen, Essen, Germany

5 Department of Dermatology, Venerology and Allergology, University Hospital Essen, Essen, Germany

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BMC Medical Genetics 2013, 14:23  doi:10.1186/1471-2350-14-23

Published: 8 February 2013

Additional files

Additional file 1: Table S1:

Result of the SNPs belonging to the same clump of the top associated SNP. The SNPs in the clump of the top associated SNP are selected based on pruning technique implemented as clump procedure in PLINK. SNPs marked in bold are the top associated SNP which are presented in Table 2.

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Additional file 2: Table S2:

Result of the SNPs belonging to the same clump of SNPs associated with P ≤ 1x10-05 for loge(CAC score + 1). SNPs marked in bold are the top associated SNP of each clump.

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Additional file 3: Table S3:

Result of association for loge(CAC score + 1) with SNPs associated with coronary artery disease in CARDIOGRAM and coronary artery calcification in CHARGE.

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