Table 1

Baseline characteristics of subjects according to cardiovascular disease status and MTTP -164 T > C genotype in EPIC-Potsdam study
CVD free by genotype CVD by genotype
All CVD free TT CT CC P for trenda All CVD TT CT CC P for trenda
n 1 978 1 096 742 140 324 178 126 20
age, yrs 49.8 ± 0.2 49.5 ± 0.3 49.2 ± 0.3 49.4 ± 0.7 0.543 54.9 ± 0.5 56.1 ± 0.6 54.1 ± 0.7 56.6 ± 1.7 0.223
Men, % 36.8 36.7 35.3 35.0 0.687 58.5 64.3 60.9 69.4 0.654
Abdominal obesity, %b 21.4 20.9 20.3 18.8 0.567 26.9 32.2 30.9 30.0 0.837
Obesity, %c 14.9 14.5 15.5 9.7 0.134 18.4 19.9 19.4 19.6 0.975
Hypertension, % 47.6 45.6 44.7 43.7 0.592 60.3 70.8 68.3 49.0 0.114
Current smokers, % 21.4 21.2 22.5 21.4 0.957 39.7 35.7 31.6 47.9 0.264
High education, % 41.7 44.2 38.7 44.4 0.978 34.1 31.8 30.3 36.1 0.699
High sport activity, % 24.8 25.2 24.4 27.5 0.230 19.9 18.0 13.0 23.5 0.534
Cholesterol, mg/dL 191 ± 0.9 189 ± 1.2 192 ± 1.5 195 ± 3.4 0.036 198 ± 2.3 210 ± 3.3 199 ± 3.9 199 ± 9.7 0.033
HDL-cholesterol, mg/dL 52 ± 0.3 52 ± 0.4 52 ± 0.5 52 ± 1.2 0.840 50 ± 0.8 50 ± 1.1 51 ± 1.3 47 ± 3.2 0.575
LDL-cholesterol, mg/dL 114 ± 0.8 112 ± 1.0 115 ± 1.2 116 ± 2.8 0.026 120 ± 1.9 128 ± 2.7 121 ± 3.2 129 ± 7.9 0.305
Triglyceride, mg/dLd 107 (105-110) 105 (101-108) 108 (104-112) 114 (104-124) 0.087 118 (111-125) 131 (120-144) 116 (104-129) 99 (76-129) 0.016
Alcohol consumption, g/day 8.0 (7.5-8.5) 8.2 (7.6-8.9) 7.5 (6.8-8.2) 9.5 (7.6-11.7) 0.871 5.9 (5.1-6.9) 5.5 (4.3-7.0) 5.8 (4.4-7.6) 3.9 (2.0-7.9) 0.663

aDetermined from linear regression model adjusted for age and sex (where appropriate) in reference to CVD free and CVD by genotype. Age was adjusted for sex. Sex was adjusted for age.

bAbdominal obesity was defined according to the ATP III criteria [41] based on the following waist circumference cut-off points: men ≥ 102 cm and women ≥ 88 cm.

cObesity was defined as BMI ≥ 30 kg/m2.

dGeometric means and 95% (CI) all such values.

di Giuseppe et al.

di Giuseppe et al. BMC Medical Genetics 2013 14:19   doi:10.1186/1471-2350-14-19

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