Additional file 5: Figure S2.

Methylation levels and significance of non-FMR1 FXS-associated loci. Top two panels show the methylation levels (y-axis) in FXS (orange squares) and control (blue crosses) individuals at several loci near the two significant non-FMR1 FXS-associated loci. Bottom two panels depict the P-values (−log(P-value); y-axis) for each probe generated by the mixed-effect linear model. Red line indicates the Bonferroni cutoff of 0.05. Only one probe from each region shown is significant at P <0.05. Position of probes (x-axis) in all four panels is relative to HG-19 coordinates for chromosomes 19 and 6, KLK15 and MICA, respectively.

Format: PDF Size: 126KB Download file

This file can be viewed with: Adobe Acrobat Reader

Alisch et al. BMC Medical Genetics 2013 14:18   doi:10.1186/1471-2350-14-18