Open Access Research article

Potential contribution of SIM2 and ETS2 functional polymorphisms in Down syndrome associated malignancies

Arpita Chatterjee1, Samikshan Dutta16, Sanjit Mukherjee2, Nupur Mukherjee3, Avirup Dutta2, Ashis Mukherjee4, Swagata Sinha1, Chinmay Kumar Panda3, Keya Chaudhuri2, Ananda L Roy5 and Kanchan Mukhopadhyay1*

Author Affiliations

1 Manovikas Biomedical Research and Diagnostic Centre, MRIH, 482, Madudah, Plot I-24, Sec.-J, E.M. Bypass, Kolkata, 700107, India

2 Indian Institute of Chemical Biology, Kolkata, India

3 Chittaranjan National Cancer Institute, Kolkata, India

4 Netaji Subhash Chandra Bose Cancer Research Institute, Kolkata, India

5 Tufts University School of Medicine, Boston, MA, USA

6 Present address: Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Nebraska, USA

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BMC Medical Genetics 2013, 14:12  doi:10.1186/1471-2350-14-12

Published: 23 January 2013

Additional files

Additional file 1:

Table S1. Sites of overexpression and underexpression of SIM2 and ETS2. S2: Possible downstream genes of SIM2 and ETS2 identified by in silico analysis. S3: Details of allelic and genotypic association test of studied SNPs. S4: Comparative analysis of haplotypes in different study group.

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