Table 1

Characteristics of the case–control studies included in meta-analysis
Age group Hypercalciuria in case group Case (n) Control (n) VDR polymorphisms Genotyping method Quality score
First author Year Country Ethnicity Composition (HWE)
Ruggiero [10] 1999 Italy Caucasian Adult Mixed* NA 27 150 BsmI (No) PCR-RFLP 4
Jackman [11] 1999 USA Caucasian NA All Calcium 17 37 TaqI (No) PCR-RFLP 3
Chen a [12] 2001 China Asian Adult NA Calcium 124 90 BsmI (No) PCR-RFLP 4
Chen b [13] 2001 China Asian Adult NA Calcium 146 90 FokI (Yes) PCR-RFLP 4
Nishijima [14] 2002 Japan Asian Adult NA Calcium 83 83 ApaI (Yes), TaqI (Yes) PCR-RFLP 5
Mossetti [15] 2003 Italy Caucasian Adult NA Calcium 220 114 BsmI (Yes), TaqI (No) PCR-RFLP 5
Ozkaya [16] 2003 Turkey Caucasian Children All Calcium 64 90 ApaI (No), BsmI (Yes), TaqI (Yes) PCR-RFLP 4
Wang a [17] 2003 China Asian Adult Mixed* Calcium 150 80 ApaI (Yes), FokI (Yes), TaqI (Yes) PCR-RFLP 3
Relan [18] 2004 India Asian Adult Mixed* Calcium 150 100 BsmI (No), FokI (No) PCR-RFLP 3
Rendina [19] 2004 Italy Caucasian Adult All Calcium 159 124 ApaI (Yes), FokI (Yes) PCR-RFLP 6
Hu [20] 2004 China Asian Adult Mixed* Calcium 186 90 ApaI (Yes), FokI (Yes), TaqI (Yes) PCR-RFLP 5
Bid a [21] 2005 India Asian Adult Mixed* Calcium 138 166 FokI (No) PCR-RFLP 4
Bid b [22] 2005 India Asian Children NA Calcium 50 60 FokI (Yes) PCR-RFLP 5
Gunes [23] 2006 Turkey Caucasian Adult NA Calcium 110 150 ApaI (Yes), BsmI (Yes), TaqI (Yes) PCR-RFLP 6
Liu [24] 2007 China Asian Adult NA Calcium 235 231 FokI (Yes) PCR-RFLP 6
Moyano [25] 2007 Spain Caucasian Adult NA Calcium 51 21 ApaI (Yes), BsmI (Yes), TaqI (Yes) PCR-RFLP 3
Seyhan [26] 2007 Turkey Caucasian Children Mixed* Calcium 80 40 TaqI (No) PCR-RFLP 4
Wang b [27] 2009 China Asian Miexd NA Calcium 90 90 ApaI (No), FokI (No) PCR-RFLP 5
Mittal [28] 2010 India Asian Adult NA NA 125 150 ApaI (Yes), FokI (No), TaqI (No) PCR-RFLP 5
Seo [29] 2010 Korea Asian Miexd NA Calcium 102 535 ApaI (No), FokI (No), TaqI (No) PCR-RFLP 5
Basiri [30] 2012 Iran Caucasian Adult NA Calcium 106 109 FokI (No), TaqI (No) PCR-SSCP 5
Wang c [31] 2012 China Asian Adult NA Calcium 464 450 ApaI (Yes), BsmI (Yes), FokI (Yes), TaqI (Yes) PCR-RFLP 6
Ruan [32] 2012 China Asian Adult NA Calcium 169 156 FokI (No) PCR-RFLP 4

*Data for hypercalciuria patients could be extracted.

HWE, Hardy-Weinberg equilibrium; PCR, polymerase chain reaction; RFLP, restriction fragment length polymorphism; SSCP, single-strand conformational polymorphism; NA, not available.

Zhang et al.

Zhang et al. BMC Medical Genetics 2013 14:104   doi:10.1186/1471-2350-14-104

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