Table 3

Local replication of previously reported GWAS associations1 in a cohort of African Americans
Index SNP Local SNP R2 Chr Position Minor Allele (Freq HUFS, Freq CEU) Nearby Gene Trait Local SNP Values)
Beta (SE) P-value2
rs2972146 rs2943652 1 2 226816690 C (0.38, 0.40) IRS1 HDL 3.0 (1.1) 0.01
rs3764261 rs173539 1 16 55545545 T (0.30, 0.37) CETP HDL 4.3 (1.2) 0.0003
rs1800775 0.5 16 55552737 C (0.45, 0.49) CETP HDL −2.5 (1.0) 0.03
rs4783961 0.6 16 55552395 A (0.37, 0.51) CETP HDL 4.6 (1.3) 0.0009
rs7941030 rs6589939 0.9 11 122023735 G (0.35, 0.39) UBASH3B TC −6.7 (2.1) 0.005

1Teslovich et al., Nature, 2010; 2P-values have been adjusted for the effective degrees of freedom within the LD window surrounding the index SNP.

Adeyemo et al.

Adeyemo et al. BMC Medical Genetics 2012 13:88   doi:10.1186/1471-2350-13-88

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