Table 2

Exact replication of previously reported GWAS associations1 in a cohort of African Americans
SNP Chr Position Minor Allele(Freq HUFS, Freq CEU) Nearby Gene Trait HUFS Previous Report
Beta (SE) P-value Beta (SE) P-value
rs10401969 19 19268718 G (0.17, 0.10) CILP2/SF4 TG −8.3 (2.8) 0.006 −7.8 (0.8) 1.6 x 10-29
rs11869286 17 35067382 G (0.26, 0.68) STARD3 HDL 2.1 (0.9) 0.02 −0.5 (0.08)2 2.8 x 10-14
rs12678919 8 19888502 G (0.11, 0.12) LPL TG −9.0 (4.4) 0.01 −13.6 (0.6) 1.5 x 10-115
rs2081687 8 59551119 T (0.22, 0.33) CYP7A1 LDL 5.2 (2.5) 0.04 0.95 (0.2) 3.9 x 10-9
rs2131925 1 62798530 T (0.37, 0.68) ANGPTL3 TC 4.5 (2.3) 0.04 −2.6 (0.2)2 4.9 x 10-41
rs4420638 19 50114786 C (0.21, 0.18) APOE HDL −2.3 (0.9) 0.02 −1.1 (0.1) 4.4 x 10-21
rs629301 1 109619829 G (0.36, 0.30) SORT1 LDL −5.4 (1.9) 0.005 −5.7 (0.2) 9.7 x 10-171

1Teslovich et al., Nature, 2010; 2The minor allele for HUFS is the major allele in previous report, thus the direction of effect should be reversed for comparison.

Adeyemo et al.

Adeyemo et al. BMC Medical Genetics 2012 13:88   doi:10.1186/1471-2350-13-88

Open Data