Open Access Highly Accessed Research article

UMOD as a susceptibility gene for end-stage renal disease

Anna Reznichenko1*, Carsten A Böger2, Harold Snieder3, Jacob van den Born1, Martin H de Borst1, Jeffrey Damman4, Marcory CRF van Dijk5, Harry van Goor5, Bouke G Hepkema6, Jan-Luuk Hillebrands5, Henri GD Leuvenink4, Jan Niesing4, Stephan JL Bakker1, Marc Seelen1, Gerjan Navis1 and On behalf of the REGaTTA (REnal GeneTics TrAnsplantation) Groningen group

Author Affiliations

1 Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, A. Deusinglaan 1, Groningen, 9713AV, the Netherlands

2 Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany

3 Department of Epidemiology, Unit of Genetic Epidemiology & Bioinformatics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands

4 Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands

5 Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands

6 Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands

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BMC Medical Genetics 2012, 13:78  doi:10.1186/1471-2350-13-78

Published: 5 September 2012

Additional files

Additional file 1:

Table S1. Distribution of primary diseases in relation to UMOD rs12917707 genotype in ESRD patients. Table S2. Predictors of GF (univariate Cox regression analysis) in 1066 renal transplant recipients followed up for a median [IQR] 5.5 [2.9-8.8] years after transplantation. Figure S1. Uromodulin urinary concentration in 282 renal transplant recipients at 4.2 [2.2-6.1] yrs post-transplant by donor and recipient genotype stratified by presence (carriers) or absence (non-carriers) of UMOD rs12917707 minor allele.

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