Table 2

ORs and heterogeneity results for the genetic contrasts ofMTHFRA1298C polymorphism for ALL risk
Genetic model Studies I2, P, Q Testa Fixed-effect Random-effect
(%) OR OR
All Allele contrast 29 63 0.000 0.99(0.94-1.05) 1.01(0.91-1.11)
Dominant model 29 65 0.000 0.99 (0.92-1.06) 1.02(0.90-1.16)
Recessive model 29 20 0.171 0.99(0.88-1.12) 1.00(0.86-1.17)
Additive model 29 41 0.012 0.99(0.87-1.13) 1.01(0.83-1.22)
All in HWE Allele contrast 27 64 0.000 0.99(0.94-1.05) 1.01(0.91-1.11)
Dominant model 27 66 0.000 0.99(0.92-1.07) 1.02(0.89-1.17)
Recessive model 27 26 0.113 0.99(0.87-1.22) 1.00(0.84-1.18)
Additive model 27 44 0.008 0.99(0.87-1.13) 1.01(0.82-1.24)
Children Allele contrast 22 64 0.000 1.01(0.95-1.07) 1.04(0.93-1.16)
Dominant model 22 67 0.000 1.01(0.93-1.09) 1.07(0.92-1.24)
Recessive model 22 26 0.129 1.00(0.88-1.14) 1.00(0.85-1.18)
Additive model 22 47 0.008 1.00(0.87-1.15) 1.02(0.83-1.25)
Adults Allele contrast 5 67 0.016 0.96(0.81-1.14) 0.92(0.67-1.25)
Dominant model 5 68 0.014 0.97(0.79-1.19) 0.92(0.63-1.33)
Recessive model 5 41 0.150 0.84(0.50-1.42) 0.85(0.37-1.93)
Additive model 5 51 0.086 0.84(0.49-1.42) 0.80(0.32-2.01)
East Asians Allele contrast 7 53 0.046 1.01(0.89-1.15) 1.01(0.82-1.23)
Dominant model 7 63 0.013 1.01(0.87-1.17) 1.01(0.78-1.31)
Recessive model 7 0 0.730 1.02(0.70-1.50) 1.07(0.72-1.58)
Additive model 7 0 0.671 1.03(0.70-1.51) 1.07(0.72-1.59)
Caucasians Allele contrast 12 62 0.003 0.96(0.89-1.04) 0.98(0.86-1.12)
Dominant model 12 55 0.011 0.95(0.86-1.04) 0.98(0.83-1.15)
Recessive model 12 42 0.062 0.97(0.82-1.14) 0.97(0.76-1.25)
Additive model 12 52 0.019 0.95(0.80-1.12) 0.98(0.73-1.30)

All = all of the studies meet the inclusion criteria; All in HWE = all of the studies meet the inclusion criteria except ones with genotype distribution of the controls deviating from HWE; HWE = Hardy-Weinberg Equilibrium.

a Q test is to estimate heterogeneity between studies. P < 0.10 indicates significant heterogeneity.

Wang et al.

Wang et al. BMC Medical Genetics 2012 13:77   doi:10.1186/1471-2350-13-77

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