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Open Access Research article

Methylenetetrahydrofolate Reductase Polymorphisms and Risk of Acute Lymphoblastic Leukemia-Evidence from an updated meta-analysis including 35 studies

Haigang Wang12, Jiali Wang3, Lixia Zhao24, Xinchun Liu1* and Wenjie Mi1*

Author Affiliations

1 Pharmacy Intravenous Admixture Services, Qilu Hospital, Shandong University, 44 Wenhuaxi Road, Jinan, 250012, China

2 College of Pharmacy, Shandong University, Jinan, China

3 Department of Emergency, Qilu Hospital, Shandong University, Jinan, China

4 Department of Pharmacy, Qilu Hospital, Shandong University, Jinan, China

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BMC Medical Genetics 2012, 13:77  doi:10.1186/1471-2350-13-77

Published: 4 September 2012

Additional files

Additional file 1:

Figure S1.Folate metabolism and the role of MTHFR. Modified from Wiemels et al. (5).

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Additional file 2:

Table S1.General characteristics of studies included in the meta-analysis on MTHFR polymorphisms and ALL risk.

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Additional file 3:

Table S2.MTHFRC677T genotype distribution and allele frequency in ALL cases and controls.

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Additional file 4:

Table S3.MTHFRA1298C genotype distribution and allele frequency in ALL cases and controls.

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Additional file 5:

Figure S2.Sensitive analysis to assess the influence of a single study in the meta-analysis on MTHFR C677T polymorphism and the risk of ALL. Allele contrast was used in sensitive analysis. N, non-Caucasians, admixture of Amerindians, Europeans and Africans; W, mainly Brazilians of Caucasian descent.

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Additional file 6:

Figure S3.Sensitive analysis to assess the influence of a single study in the meta-analysis on MTHFR A1298C polymorphism and the risk of ALL. Allele contrast was used in sensitive analysis. C, Chinese; M, Malays; N, non-Caucasians, admixture of Amerindians, Europeans and Africans; W, mainly Brazilians of Caucasian descent.

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Additional file 7:

Table S4.Results of the pooled OR and the corresponding 95% CIs for each combined genotype for MTHFR C677T and A1298C polymorphisms.

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Additional file 8:

Table S5.Characteristics of meta-analyses regarding MTHFR polymorphisms and ALL risk. (DOC 42 kb)

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