Table 5

Clinical findings stratified by SNPs in the whole group of patients
FPN1 -8CG Onset Duration EDSS PI MSSS
−8CC 33.5±9.8 9.3±7.35 2.73±2.07 0.58±0.78 3.72±2.66
(n=244) (11.0-60.0) (0.3-38.0) (1.0-10) (0.03-7.0) (0.13-9.99)
−8CG 31.92±10.45 9.32±7.95 3.07±2.48 0.64±1.24 4.09±2.78
(n=141) (14.0-61.0) (0.2-50.0) (1.0-9.0) (0.03-10) (0.15-9.97)
−8GG 33.38±12.3 7.0±5.17 3.59±2.43 1.11±2.01 5.08±2.98
(n=29) (15.0-53.0) (0.2-20.4) (1.0-9.0) (0.1-10.0) (0.78-9.97)
P uncorrected NS 0.05 0.045 0.01 0.01
(P corrected) (0.05) (0.05)
HFE C282Y
282CC 32.3±10.37 9.19±7.49 2.9±2.25 0.63±1.07 3.9±2.73
(n=401) (11.0-60.0) (0.2-50.0) (1.0-10) (0.03-10.0) (0.13-9.99)
282CY 33.62±11.12 7.27±5.35 3.16±2.21 0.58±1.54 4.64±2.91
(n=13) (16.0-61.0) (1.0-27.0) (1.0-9.0) (0.13-1.3) (1.13-9.92)
P-value NS NS NS NS NS
HFE H63D
63HH 32.75±10.94 8.92±7.12 2.89±2.23 0.62±0.98 3.99±2.78
(n=288) (11.0-61.0) (0.2-50.0) (1.0-10) (0.03-10) (0.15-9.99)
63HD 30.97±8.94 9.8±8.2 2.81±2.21 0.55±1.01 3.65±2.55
(n=113) (14.0-56.0) (0.5-38.0) (1.0-9.0) (0.03-10) (0.13-9.97)
63DD 36.1±8.23 8.43±7.57 3.96±2.93 1.63±2.6 5.33±3.03
(n=13) (28.0-55.0) (0.2-22.2) (1.0-8.5) (0.2-7.5) (1.28-9.99)
P uncorrected 0.06 NS NS 0.009 0.03
(P corrected) (NS) (0.045) (NS)
HEPC -582AG
−582AA 29.57±9.86 9.54-7.3 2.59±2.06 0.57±.1.14 3.39±2.56
(n=205) (14.0-61.0) (0.2-38.0) (1.0-9.0) (0.03-10) (0.13-9.97)
−582AG 35.1±9.92 8.78±7.78 3.01±2.22 0.63±0.94 4.26±2.7
(n=175) (11.0-56.0) (0.2-50.0) (1.0-9.0) (0.04-10.0) (0.29-9.98)
−582GG 35.2±11.56 8.55±6.45 4.24±2.87 0.96±1.38 5.6±3.06
(n=34) (20.0-56.0) (0.5-27.0) (1.0-10) (0.13-7.0) (1.13-9.99)
P uncorrected 0.07* NS 0.003 0.08 0.001
(P corrected) (NS) (0.015) (NS) (0.005)
TF P570S
570PP 32.38±10.44 8.42±6.97 2.72±2.15 0.69±1.26 3.78±2.66
(n=278) (11.0-56.0) (0.2 34.0) (1.0-10) (0.03-10.0) (0.15-9.99)
570PS 32.32±10.53 11.08±8.24 3.38±2.41 0.48±0.52 4.28±2.92
(n=122) (14.0-61.0) (0.5-50.0) (1.0-9.0) (0.03-4.0) (0.13-9.97)
570SS 32.53±8.43 6.52±6.17 2.47±2.05 0.77±0.89 4.1±2.52
(n=14) (21.0-51.0) (0.5-22.0) (1.0-9.0) (0.15-3.0) (1.13-9.73)
P uncorrected NS 0.06 NS NS NS
(P corrected) (NS)

Values shown are mean, standard deviation (SD), and (ranges). All P-values shown are obtained computing the rare homozygous genotype vs the rest of genotypes. *Computing G-carriers vs AA-genotype P-value <0.0001. Significant P-values, and those <0.10 are reported. NS, not significant.

Gemmati et al.

Gemmati et al. BMC Medical Genetics 2012 13:70   doi:10.1186/1471-2350-13-70

Open Data