Table 3

Association of SNPs in theTLR7-TLR8region with AR phenotype in the Chinese population
Association test Skin prick test
Gene SNP ID Position* Alleles MAF HW Allele M + F Allele M Allele F Genotype B. tp D. pt#
TLR7 rs179021 12889763 T/G 0.01 1.0 0.72 0.42 0.62 0.62 0.70 0.12
TLR7 rs179020 12889857 G/A 0.25 0.26 0.65 0.38 0.36 0.56 0.021 (0.32) 0.010 (0.025)
TLR7 rs179019 12889969 C/A 0.25 0.34 0.78 0.36 0.44 0.70 0.022 (0.32) 0.0090 (0.025)
TLR7 rs179016 12894442 G/C 0.12 1.0 0.61 0.62 0.81 0.85 0.094 0.013 (0.025)
TLR7 rs179014 12899765 G/A 0.00 1.0 0.80 - 0.91 0.91 0.091 0.24
TLR7 rs179013 12901471 G/A 0.01 1.0 0.85 0.42 0.76 0.76 0.72 0.14
TLR7 rs179012 12901562 G/A 0.06 1.0 0.66 0.92 0.75 0.95 0.67 0.011 (0.025)
TLR7 rs179011 12901960 G/T 0.01 1.0 0.65 0.42 0.58 0.58 0.73 0.13
TLR7 rs179010 12902885 C/T 0.35 0.18 0.86 0.45 0.52 0.59 0.078 0.0046 (0.025)
TLR7 rs179008 12903659 A/T 0.00 1.0 0.37 - 0.47 0.47 0.76 0.43
TLR7 rs864058 12906030 G/A 0.00 0.0091 0.92 0.57 0.85 0.39 0.28 0.88
TLR7 rs179007 12910322 A/G 0.00 0.0044 0.17 - 0.25 0.55 0.76 0.43
TLR7 rs179006 12910521 G/A 0.00 0.0036 0.17 - 0.25 0.55 0.76 0.43
TLR7 rs2269809 12910619 T/G 0.16 0.20 0.38 0.061 0.97 0.27 0.59 0.18
TLR7 rs5935438 12913022 G/C 0.15 0.017 0.34 0.056 0.92 0.27 0.77 0.26
TLR8 rs178998 12917787 T/C 0.16 0.053 0.18 0.024 (0.072) 0.74 0.34 0.43 0.56
TLR8 rs3788935 12922659 G/A 0.17 0.10 0.27 0.025 (0.072) 0.85 0.80 0.45 0.14
TLR8 rs5741883 12924221 C/T 0.02 0.35 0.66 0.84 0.64 0.39 0.27 0.53
TLR8 rs17256081 12926045 T/C 0.15 0.018 0.20 0.010 (0.072) 0.86 0.54 0.84 0.19
TLR8 rs4830805 12927759 A/G 0.19 0.29 0.42 0.016 (0.072) 0.84 0.74 0.40 0.053
TLR8 rs1548731 12927947 C/T 0.02 0.68 0.33 0.93 0.38 0.26 0.16 0.25
TLR8 rs4830808 12932334 T/C 0.23 0.41 0.16 0.054 0.58 0.85 0.091 0.057
TLR8 rs2407992 12939112 C/G 0.19 0.18 0.023 (0.33) 0.0054 (0.072) 0.30 0.59 0.12 0.45

The Hardy-Weinberg (HW) test uses both cases and controls. Male (M) and female (F) individuals were used separately and combined in the allele tests. The Kruskal-Wallis test is used on skin prick data. P-values are given for the HW and association tests.

*Position according to NCBI build 37.1.

Allele frequency of second allele.

Blomia tropicalis.

#Dermatophagoides pteronyssinus.

Nilsson et al.

Nilsson et al. BMC Medical Genetics 2012 13:66   doi:10.1186/1471-2350-13-66

Open Data