Table 5

Significant (Uncorrected) Analyses of SNPs Previously Reported as NTD Risk Factors in this Population
Gene/SNP MAF* Cohort** Model OR 95% CI (LL) 95% CI (UL) P
MTHFR rs1801133 677 C > T 0.32 Combined LR CC Continuous 1.23 1.05 1.45 0.011
Combined LR CC Recessive 1.26 1.01 1.57 0.041
Combined LR CC Dominant 1.44 1.04 2.00 0.029
Combined LR MC Continuous 1.22 1.04 1.43 0.017
Combined LR MC Recessive 1.25 1.01 1.57 0.045
MTHFD1 rs2236225 R653Q 0.46 Primary LR MC Continuous 1.35 1.06 1.71 0.014
Primary LR MC Dominant 1.97 1.28 3.04 0.002
Combined LR MC Dominant 1.48 1.14 1.92 0.003
Primary LL Case effect, dominant 0.53 0.30 0.93 0.026
Combined LL TDT 0.80 0.65 0.99 0.039
Combined LL Case effect, dominant 0.60 0.42 0.86 0.005
TCblR rs2336573 G220R 0.04 Combined LR CC Dominant .*** 0.013

*For each SNP, the minor allele was evaluated as the risk allele.

** Primary: 320 triads, 341 controls. Combined: 570 triads, 999 controls.

*** (.) = Failure to converge. Pexact is shown.

Pangilinan et al.

Pangilinan et al. BMC Medical Genetics 2012 13:62   doi:10.1186/1471-2350-13-62

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