Figure 2.

Linkage Disequilibrium Relationships Between SNPs Significantly Associated with NTDs. Sixty-eight SNPs were associated with case or maternal effects (p < 0.01, uncorrected). Of these, 56 SNPs occur in the same gene as at least one other significantly associated SNP. Their D’ (red scale) and r² (gray scale) relationships are shown. These SNPs are plotted by relative position. Haplotype blocks defined by a Solid Spine of LD (D’) are outlined in black. Each SNP is numbered and the gene and dbSNP accession number for each are: 1) MTHFR_rs17367504; 2) MTHFR_rs17037425; 3) ARID1A_rs11247593; 4) ARID1A_rs11247594; 5) ARID1A_rs11247596; 6) MTR_rs10733117; 7) MTR_rs10925260; 8) CUBN_rs11591606; 9) CUBN_rs1801222; 10) CUBN_rs11254375; 11) CUBN_rs7070148; 12) CUBN_rs2273737; 13) FOLH1_rs383028; 14) FOLH1_rs16906205; 15) MTHFD1_rs11627525; 16) MTHFD1_rs2236225; 17) ALDH1A2_rs7169289; 18) ALDH1A2_rs6493978; 19) PEMT_rs4646402; 20) PEMT_rs1108579; 21) PEMT_rs16961845; 22) PEMT_rs11656215; 23) RAI1_rs11654526; 24) RAI1_rs9914733; 25) RAI1_rs11658846; 26) ENOSF1_rs1059384; 27) ENOSF1_rs10502289; 28) ADA_rs6031682; 29) ADA_rs452159; 30) ADA_rs406383; 31) ADA_rs2299686; 32) ADA_rs427483; 33) ADA_rs6094017; 34) GART_rs2070388; 35) GART_rs4817580; 36) FTCD_rs7280485; 37) FTCD_rs2839127; 38) COMT_rs737865; 39) COMT_rs174675; 40) PDGFRA_rs2114039; 41) PDGFRA_rs9993187; 42) MTHFD1L_rs2295083; 43) MTHFD1L_rs17080476; 44) MTHFD1L_rs487637; 45) MTHFD1L_rs6923486; 46) MTHFD1L_rs12524884; 47) MTHFD1L_rs11155772; 48) MTHFD1L_rs12199063; 49) MTHFD1L_rs4869987; 50) MFTC_rs10112450; 51) MFTC_rs1865855; 52) MFTC_rs17803441; 53) MFTC_rs750606; 54) MFTC_rs3134260; 55) CDKN2A_rs7041637; 56) CDKN2A_rs3218009