Research article
No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations
1 Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan
2 The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Japan
3 Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
4 Department of Internal Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
5 Department of Internal Medicine, Teine Keijinkai Hospital, Sapporo, Japan
6 First Department of Internal Medicine, Iwate Medical University, Iwate, Japan
7 Division of Gastroenterology and Hepatology, Internal Medicine, Saitama Medical University, Saitama, Japan
8 Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
9 Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan
10 Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
11 Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
12 Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
13 Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
14 National Hospital Organization Osaka National Hospital, Osaka, Japan
15 Division of Hepatology and Pancreatology, Kawasaki Medical College, Kurashiki, Japan
16 Second department of Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan
17 Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan
18 Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Fukuoka, Japan
19 Department of International Medicine, Yonsei University College of Medicine, Seoul, Korea
20 Department of Medicine, the University of Hong Kong, Queen Mary Hospital, Hong Kong, China
BMC Medical Genetics 2012, 13:47 doi:10.1186/1471-2350-13-47
Published: 19 June 2012Abstract
Background
A recent genome-wide association study (GWAS) using chronic HBV (hepatitis B virus) carriers with and without hepatocellular carcinoma (HCC) in five independent Chinese populations found that one SNP (rs17401966) in KIF1B was associated with susceptibility to HCC. In the present study, a total of 580 HBV-derived HCC cases and 1351 individuals with chronic hepatitis B (CHB) or asymptomatic carrier (ASC) were used for replication studies in order to evaluate the reported association with HBV-derived HCC in other East Asian populations.
Results
We did not detect any associations between rs17401966 and HCC in the Japanese cohorts (replication 1: OR = 1.09, 95 % CI = 0.82-1.43; replication 2: OR = 0.79, 95 % CI = 0.54-1.15), in the Korean cohort (replication 3: OR = 0.95, 95 % CI = 0.66-1.36), or in the Hong Kong Chinese cohort (replication 4: OR = 1.17, 95 % CI = 0.79-1.75). Meta-analysis using these cohorts also did not show any associations with P = 0.97.
Conclusions
None of the replication cohorts showed associations between rs17401966 and HBV-derived HCC. This may be due to differences in the genetic diversity among the Japanese, Korean and Chinese populations. Other reasons could be the high complexity of multivariate interactions between the genomic information and the phenotype that is manifesting. A much wider range of investigations is needed in order to elucidate the differences in HCC susceptibility among these Asian populations.
