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Open Access Research article

No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations

Hiromi Sawai1*, Nao Nishida12, Hamdi Mbarek3, Koichi Matsuda3, Yoriko Mawatari2, Megumi Yamaoka1, Shuhei Hige4, Jong-Hon Kang5, Koichi Abe6, Satoshi Mochida7, Masaaki Watanabe8, Masayuki Kurosaki9, Yasuhiro Asahina9, Namiki Izumi9, Masao Honda10, Shuichi Kaneko10, Eiji Tanaka11, Kentaro Matsuura12, Yoshito Itoh13, Eiji Mita14, Masaaki Korenaga15, Keisuke Hino15, Yoshikazu Murawaki16, Yoichi Hiasa17, Tatsuya Ide18, Kiyoaki Ito2, Masaya Sugiyama2, Sang Hoon Ahn19, Kwang-Hyub Han19, Jun Yong Park19, Man-Fung Yuen20, Yusuke Nakamura3, Yasuhito Tanaka12, Masashi Mizokami2 and Katsushi Tokunaga1

Author Affiliations

1 Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

2 The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Japan

3 Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

4 Department of Internal Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan

5 Department of Internal Medicine, Teine Keijinkai Hospital, Sapporo, Japan

6 First Department of Internal Medicine, Iwate Medical University, Iwate, Japan

7 Division of Gastroenterology and Hepatology, Internal Medicine, Saitama Medical University, Saitama, Japan

8 Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan

9 Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan

10 Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan

11 Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan

12 Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan

13 Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan

14 National Hospital Organization Osaka National Hospital, Osaka, Japan

15 Division of Hepatology and Pancreatology, Kawasaki Medical College, Kurashiki, Japan

16 Second department of Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan

17 Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan

18 Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Fukuoka, Japan

19 Department of International Medicine, Yonsei University College of Medicine, Seoul, Korea

20 Department of Medicine, the University of Hong Kong, Queen Mary Hospital, Hong Kong, China

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BMC Medical Genetics 2012, 13:47  doi:10.1186/1471-2350-13-47

Published: 19 June 2012

Abstract

Background

A recent genome-wide association study (GWAS) using chronic HBV (hepatitis B virus) carriers with and without hepatocellular carcinoma (HCC) in five independent Chinese populations found that one SNP (rs17401966) in KIF1B was associated with susceptibility to HCC. In the present study, a total of 580 HBV-derived HCC cases and 1351 individuals with chronic hepatitis B (CHB) or asymptomatic carrier (ASC) were used for replication studies in order to evaluate the reported association with HBV-derived HCC in other East Asian populations.

Results

We did not detect any associations between rs17401966 and HCC in the Japanese cohorts (replication 1: OR = 1.09, 95 % CI = 0.82-1.43; replication 2: OR = 0.79, 95 % CI = 0.54-1.15), in the Korean cohort (replication 3: OR = 0.95, 95 % CI = 0.66-1.36), or in the Hong Kong Chinese cohort (replication 4: OR = 1.17, 95 % CI = 0.79-1.75). Meta-analysis using these cohorts also did not show any associations with P = 0.97.

Conclusions

None of the replication cohorts showed associations between rs17401966 and HBV-derived HCC. This may be due to differences in the genetic diversity among the Japanese, Korean and Chinese populations. Other reasons could be the high complexity of multivariate interactions between the genomic information and the phenotype that is manifesting. A much wider range of investigations is needed in order to elucidate the differences in HCC susceptibility among these Asian populations.

Keywords:
Hepatitis B; hepatocellular carcinoma; candidate SNP; replication study; genome-wide association study