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Open Access Research article

TGFB1 genetic polymorphisms and coronary heart disease risk: a meta-analysis

Yingchang Lu12*, Jolanda MA Boer2, Roza M Barsova3, Olga Favorova3, Anuj Goel4, Michael Müller1, Edith JM Feskens1 and and on behalf of PROCARDIS CARDIoGRAM Consortium

Author Affiliations

1 Division of Human Nutrition, Wageningen University and Research Center, PO Box 8129, 6700, EV, Wageningen, The Netherlands

2 National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720, BA, Bilthoven, The Netherlands

3 Russian Cardiology Scientific and Production Center, Russian State Medical University, 121552, Moscow, Russia

4 Department of Cardiovascular Medicine, University of Oxford, Oxford, UK

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BMC Medical Genetics 2012, 13:39  doi:10.1186/1471-2350-13-39

Published: 18 May 2012

Abstract

Background

Genetic variations in TGFB1 gene have been studied in relation to coronary heart disease (CHD) risk, but the results were inconsistent.

Methods

We performed a systematic review of published studies on the potential role of TGFB1 genetic variation in CHD risk. Articles that reported the association of TGFB1 genetic variants with CHD as primary outcome were searched via Medline and HuGE Navigator through July 2011. The reference lists from included articles were also reviewed.

Results

Data were available from 4 studies involving 1777 cases and 7172 controls for rs1800468, 7 studies involving 5935 cases and 10677 controls for rs1800469, 7 studies involving 6634 cases and 9620 controls for rs1982073, 5 studies involving 5452 cases and 9999 controls for rs1800471, and 4 studies involving 5143 cases and 4229 controls for rs1800472. The pooled odds ratios (ORs) for CHD among minor T allele carriers of rs1800469, minor C allele carriers of rs1982073, and minor C allele carriers of rs1800471 versus homozygous major allele carriers was 1.14 (95% confidence interval [CI]: 1.05-1.24), 1.18 (95% CI: 1.04-1.35), and 1.16 (95% CI: 1.02-1.32), respectively. No substantial heterogeneity for ORs was detected among the included Caucasian populations for all SNPs. However, for rs1800471, the statistical significance disappeared after adjusting for potential publication bias. No significant association was found between rs1800468 and rs1800472 variants and CHD risk.

Conclusion

Minor allele carriers of two genetic variants (rs1800469 and rs1982073) in TGFB1 have a 15% increased risk of CHD.