Table 4

Association of 11 SNPs and the Genotype Score with mortality by race-ethnicity, Third National Health and Nutrition Examination Survey (NHANES III)
Mortality at 13.5 years
with 0, 1, or 2 Risk Allele
Race-ethnicity SNPs N 0 1 2 SNP per-risk alelle increase in mortality (OR) (95% CI) p-value1 mortality events Age and race standardized weighted mortality (%) per 1000 person-years (95% CI) 11 SNP Genotype Score per-risk alelle increase in mortality (OR) (95% CI) p-value3
143 12.8 (11.0–14.6) 1.07 (0.99–1.16) 0.09
Non-Hispanic White rs2022003 1,226 52.8 39.1 8.1 1.12 (0.81–1.55) 0.48
rs552976 1,192 9.9 41.5 48.6 0.93 (0.68–1.27) 0.68
rs1800562 1,204 0.1 8.0 91.9 1.07 (0.45–2.55) 0.88
rs1799884 1,207 69.2 27.6 3.3 0.98 (0.68–1.40) 0.90
rs4737009 1,183 57.7 35.1 7.2 0.97 (0.65–1.47) 0.91
rs6474359 1,174 0.1 6.8 93.1 0.91 (0.48–1.69) 0.76
rs16926246 1,206 2.5 20.7 76.8 1.34 (0.88–2.05) 0.17
rs10830956 1,173 49.3 42.9 7.9 1.14 (0.79–1.65) 0.48
rs282606 1,183 74.4 22.9 2.7 0.85 (0.58–1.22) 0.37
rs1046896 1,205 47.4 42.9 9.7 1.11 (0.80–1.54) 0.52
rs855791 1,183 33.2 48.3 18.5 1.14 (0.81–1.62) 0.45
100 19.4 (15.8–22.9) 1.04(0.95–1.14) 0.39
Non-Hispanic Black rs2022003 869 55.2 39.2 5.6 1.40 (0.97–2.04) 0.07
rs552976 882 10.2 42.8 47.0 0.96 (0.67–1.39) 0.84
rs1800562 887 0.1 7.1 92.8 2.81 (1.11–7.13) 0.03
rs1799884 888 68.7 28.2 3.1 0.96 (0.65–1.43) 0.86
rs4737009 861 19.0 51.7 29.3 1.11 (0.77–1.59) 0.57
rs6474359 853 6.4 38.6 55.1 0.73 (0.51–1.03) 0.08
rs16926246 885 1.6 19.7 78.7 1.13 (0.66–1.92) 0.66
rs10830956 832 37.7 47.0 15.3 1.18 (0.84–1.67) 0.34
rs282606 859 20.2 50.8 29.1 0.93 (0.68–1.27) 0.63
rs1046896 888 50.2 40.9 8.9 1.17 (0.85–1.63) 0.33
rs855791 857 70.2 25.6 4.2 0.93 (0.63–1.38) 0.73
55 14.5 (12.0–16.9) 1.03 (0.90–1.18) 0.71
Mexican American rs2022003 896 41.9 45.6 12.5 0.96 (0.64–1.44) 0.84
rs552976 890 13.6 41.5 44.8 0.99 (0.67–1.46) 0.97
rs1800562 904 0.1 4.8 95.1 1.30 (0.44–3.85) 0.63
rs1799884 904 68.7 27.3 4.0 0.85 (0.54–1.36) 0.50
rs4737009 884 57.6 37.1 5.2 1.33 (0.88–2.02) 0.18
rs6474359 883 0.2 6.8 93.0 0.85 (0.35–2.03) 0.71
rs16926246 904 1.3 19.4 79.3 2.04 (1.02–4.08) 0.04
rs10830956 874 59.7 33.8 6.5 0.90 (0.57–1.40) 0.64
rs282606 882 67.6 28.4 4.0 0.68 (0.41–1.12) 0.13
rs1046896 904 47.3 43.6 9.2 1.06 (0.70–1.60) 0.78
rs855791 878 30.2 50.7 19.2 0.95 (0.64–1.40) 0.80

SNP: single nucleaotide polymorphism; OR: odds ratio; CI: confidence interval.

1. p-value associated with the OR for the per-risk allele increase in mortality for each SNP.

2. p=<.0001 for the global difference in mortality across race-ethnic groups.

3. p-value associated with the OR for the per-risk allele increase in mortality for the genotype risk score.

Grimsby et al.

Grimsby et al. BMC Medical Genetics 2012 13:30   doi:10.1186/1471-2350-13-30

Open Data