Table 2

Regression coefficients of 11 HbA1c-associated SNPs on HbA1clevels by race-ethnicity, Third National Health and Nutrition Examination Survey (NHANES III)
Non-Hispanic White Non-Hispanic Black Mexican American p-value for heterogeneity3
SNPs Chr. Nearest Gene β1(SE) p-value2 β1(SE) p-value2 β1(SE) p-value2
rs2022003 1 SPTA1 0.021 (0.02) 0.34 0.024 (0.03) 0.48 0.038 (0.02) 0.09 0.75
rs552976 2 ABCB11/G6PC2 0.030 (0.02) 0.13 0.015 (0.03) 0.64 0.011 (0.02) 0.62 0.76
rs1800562 6 HFE 0.022 (0.06) 0.73 0.1041 (0.07) 0.14 0.005 (0.10) 0.96 0.27
rs1799884 7 GCK -0.003 (0.03) 0.91 -0.031 (0.04) 0.40 0.041 (0.03) 0.13 0.78
rs4737009 8 ANK1 0.047 (0.02) 0.03 0.038 (0.03) 0.20 0.052 (0.03) 0.06 0.99
rs6474359 8 ANK1 0.1024 (0.05) 0.03 0.026 (0.04) 0.49 -0.002 (0.06) 0.97 0.41
rs16926246 10 HK1 -0.050 (0.03) 0.08 0.036 (0.04) 0.37 -0.005 (0.03) 0.87 0.71
rs10830956 11 MTNR1B -0.010 (0.02) 0.62 -0.011 (0.03) 0.74 0.030 (0.03) 0.24 0.38
rs282606 13 ATP11A / 0.037 (0.03) 0.17 0.019 (0.03) 0.53 -0.015 (0.03) 0.60 0.90
rs1046896 17 FN3K 0.014 (0.02) 0.47 -0.034 (0.03) 0.24 -0.021 (0.02) 0.35 0.23
rs855791 22 TMPRSS6 0.048 (0.02) 0.01 0.025 (0.04) 0.49 0.050 (0.02) 0.02 0.52

SE: standard error; Chr.: chromosome.

1. β-coefficients (SE) (change in HbA1c per SNP risk allele) of linear regression models adjusted for age and sex.

2. p-values for β-coefficients based on Satterthwaite adjusted-F test.

3. p-values for difference in β-coefficients acris race-ethnic groups.

Grimsby et al.

Grimsby et al. BMC Medical Genetics 2012 13:30   doi:10.1186/1471-2350-13-30

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