Open Access Research article

Race-ethnic differences in the association of genetic loci with HbA1c levels and mortality in U.S. adults: the third National Health and Nutrition Examination Survey (NHANES III)

Jonna L Grimsby12, Bianca C Porneala1, Jason L Vassy12, Quanhe Yang3, José C Florez1245, Josée Dupuis67, Tiebin Liu3, Ajay Yesupriya3, Man-Huei Chang3, Renee M Ned3, Nicole F Dowling3, Muin J Khoury3, James B Meigs12* and the MAGIC Investigators8

Author Affiliations

1 General Medicine Division, Massachusetts General Hospital, Boston, MA, USA

2 Harvard Medical School, Boston, MA, USA

3 Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA, USA

4 Diabetes Unit and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA

5 Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA

6 Boston University School of Public Health, Boston, MA, USA

7 National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA

8 Meta-analysis of Glucose and Insulin related traits Consortium, a, a

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BMC Medical Genetics 2012, 13:30  doi:10.1186/1471-2350-13-30

Published: 27 April 2012

Additional files

Additional file 1:

Table S1. Weighted Risk (HbA1c-raising) allele frequencies of 11 HbA1c-associated SNPs by race-ethnicity, Third National Health and Nutrition Survey (NHANES III); Table S2. Weighted allele and genotype frequencies of 11 HbA1c-associated SNPs by race-ethnicity, Third National Health and Nutrition Examination Survey (NHANES III) versus HapMap; Table S3. Power calculations for HbA1c at alpha=0.05 and alpha=0.05/11 (Bonferroni corrected) assuming similar effect sizes to those published by Soranzo et al. (2010); Table S4. Adjusted mean HbA1c levels (%) and an 8-SNP "non-glycemic" genetic risk score by race-ethnicity, Third National Health and Nutrition Examination Survey (NHANES III); Table S5. Power calculations for mortality at alpha=0.05 and alpha=0.05/11 (Bonferroni corrected); Table S6. Number of LD blocks in 500 kb regions flanking each SNP (based on Haploview version 4.2, HapMap release 27, build 36, Phases II and III, February 2009) and Table S7. Scans for signatures of population differentiation and natural selection in 2Mb regions surrounding 10 SNPs associated with HbA1c in Europeans from Haplotter queries by SNP and queries by locus (2Mb regions).

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