Table 3

Logistic regression analysis of case/controls and mother/controls for DIP rs3832406 and SNP rs17080476 in all cleft samples
Polymorphism/Allele Name Dominant Recessive Multiplicative
OR1(95% CI2) p- value OR(95% CI) p-value OR (95% CI) p-value
Isolated CLP DIP Allele 1 Case-CTRL 1.1 (0.8, 1.5) 0.6159 1 (0.8, 1.3) 0.8468 1 (0.9, 1.2) 0.7022
Mother-CTRL 0.9 (0.6, 1.2) 0.3917 0.9 (0.7, 1.1) 0.4774 0.9 (0.8, 1.1) 0.3476
DIP Allele 2 Case-CTRL 1.1 (0.9, 1.4) 0.3358 0.8 (0.5, 1.4) 0.4926 1.1 (0.9, 1.3) 0.5534
Mother-CTRL 1.1 (0.9, 1.4) 0.2363 1.2 (0.7, 2) 0.5077 1.1 (0.9, 1.4) 0.2176
DIP Allele 3 Case-CTRL 0.9 (0.7, 1.1) 0.1928 1 (0.5, 2) 0.9158 0.9 (0.7, 1.1) 0.2349
Mother-CTRL 1 (0.8, 1.3) 0.9044 0.7 (0.3, 1.5) 0.3311 1 (0.8, 1.2) 0.8726
SNP Case-CTRL 1 (0.6, 1.8) 0.9798 0.9 (0.7, 1.1) 0.1816 0.9 (0.7, 1.1) 0.2494
Mother-CTRL 1.3 (0.7, 2.5) 0.4286 0.9 (0.7, 1.1) 0.2382 0.9 (0.8, 1.1) 0.4336
Multiple CLP DIP Allele 1 Case-CTRL 1 (0.7, 1.4) 0.9697 1 (0.8, 1.2) 0.9333 1 (0.8, 1.2) 0.9358
Mother-CTRL 0.8 (0.6, 1.2) 0.2857 0.9 (0.7, 1.2) 0.4737 0.9 (0.8, 1.1) 0.2955
DIP Allele 2 Case-CTRL 1.1 (0.9, 1.4) 0.258 0.9 (0.5, 1.6) 0.6969 1.1 (0.9, 1.3) 0.4046
Mother-CTRL 1.1 (0.9, 1.4) 0.2396 1.3 (0.8, 2.2) 0.3264 1.1 (0.9, 1.4) 0.1809
DIP Allele 3 Case-CTRL 0.9 (0.7, 1.1) 0.323 1 (0.5, 2.2) 0.9053 0.9 (0.7, 1.1) 0.3998
Mother-CTRL 1 (0.8, 1.3) 0.9303 0.7 (0.3, 1.7) 0.4316 1 (0.8, 1.2) 0.8883
SNP Case-CTRL 1 (0.5, 1.8) 0.9538 0.9 (0.7, 1.1) 0.2786 0.9 (0.8, 1.1) 0.3381
Mother-CTRL 1.2 (0.6, 2.3) 0.5906 0.9 (0.7, 1.1) 0.2905 0.9 (0.8, 1.1) 0.4526
Isolated CPO DIP Allele 1 Case-CTRL 1 (0.7, 1.4) 0.9498 1 (0.8, 1.2) 0.6933 1 (0.8, 1.2) 0.7915
Mother-CTRL 0.9 (0.6, 1.2) 0.3981 0.8 (0.6, 1) 0.0708 0.9 (0.7, 1) 0.0808
DIP Allele 2 Case-CTRL 1 (0.8, 1.3) 0.8703 0.5 (0.2, 1.1) 0.0749 1 (0.8, 1.2) 0.6497
Mother-CTRL 1 (0.8, 1.3) 0.7614 1.1 (0.6, 1.9) 0.798 1 (0.8, 1.3) 0.7284
DIP Allele 3 Case-CTRL 1.1 (0.9, 1.4) 0.3873 1.1 (0.5, 2.4) 0.7843 1.1 (0.9, 1.4) 0.3963
Mother-CTRL 1.3 (1, 1.7) 0.04313 1.1 (0.5, 2.4) 0.7368 1.2 (1, 1.5) 0.0576
SNP Case-CTRL 0.8 (0.4, 1.4) 0.4111 1 (0.8, 1.3) 0.7454 1 (0.8, 1.2) 1
Mother-CTRL 0.8 (0.4, 1.5) 0.4739 1 (0.8, 1.3) 0.8894 1 (0.8, 1.2) 0.7186
Multiple CPO DIP Allele 1 Case-CTRL 1 (0.7, 1.5) 0.9335 1 (0.8, 1.3) 0.9081 1 (0.8, 1.2) 0.8998
Mother-CTRL 0.8 (0.6, 1.2) 0.3735 0.8 (0.7, 1.1) 0.2065 0.9 (0.7, 1.1) 0.1723
DIP Allele 2 Case-CTRL 1 (0.8, 1.3) 0.8253 0.5 (0.2, 1.2) 0.1285 1 (0.8, 1.2) 0.7474
Mother-CTRL 1 (0.8, 1.3) 0.824 1 (0.5, 1.9) 0.9076 1 (0.8, 1.3) 0.882
DIP Allele 3 Case-CTRL 1.1 (0.8, 1.4) 0.5704 1 (0.4, 2.5) 0.9392 1.1 (0.8, 1.4) 0.598
Mother-CTRL 1.2 (0.9, 1.6) 0.1179 1.4 (0.6, 3.1) 0.4179 1.2 (1, 1.6) 0.1044
SNP Case-CTRL 0.9 (0.5, 1.7) 0.7393 1 (0.8, 1.3) 0.9235 1 (0.8, 1.2) 0.847
Mother-CTRL 0.7 (0.4, 1.4) 0.3247 1 (0.8, 1.3) 0.9406 1 (0.8, 1.2) 0.6925

1 OR = odds ratio

2 CI = confidence interval

3 Significant values are marked in bold.

Minguzzi et al.

Minguzzi et al. BMC Medical Genetics 2012 13:29   doi:10.1186/1471-2350-13-29

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