Table 2

TDT analysis for DIP rs3832406 and SNP rs17080476 in all cleft sample
Allele Passed Not Passed GRR1 (95% CI) P-value
DIP rs3832406 n % n %
Isolated CLP 1 194 55.6 155 44.4 1.3 (1.0, 1.5) 0.0372
2 119 47.2 133 52.8 0.9 (0.7, 1.1) 0.3781
3 88 43.8 113 56.2 0.8 (0.6, 1.0) 0.0786
Total 401 401
Multiple CLP 1 216 56.5 166 43.5 1.3 (1.1, 1.6) 0.0107
2 128 46.5 147 53.5 0.9 (0.7, 1.1) 0.2523
3 92 42.8 123 57.2 0.7 (0.6,1.0) 0.0351
Total 436 436
Isolated CPO 1 145 52.5 131 47.5 1.1 (0.9, 1.4) 0.3996
2 86 47.8 94 52.2 0.9 (0.7, 1.2) 0.5511
3 77 48.1 83 51.9 0.9 (0.7, 1.3) 0.6353
Total 308 308
Multiple CPO 1 188 52.2 172 47.8 1.1 (0.9, 1.3) 0.3992
2 115 48.9 120 51.1 1.0 (0.7, 1.2) 0.7443
3 101 47.4 112 52.6 0.9 (0.7, 1.2) 0.4512
Total 404 404
SNP rs17080476 Isolated CLP G 132 54.3 111 45.7 1.2 (0.9, 1.5) 0.1785
A 111 45.7 132 54.3
Total 243 243
Multiple CLP G 144 54.3 121 45.7 1.2 (0.9, 1.5) 0.1582
A 121 45.7 144 54.3
Total 265 265
Isolated CPO G 87 50.6 85 49.4 1.0 (0.8, 1.4) 0.8788
A 85 49.4 87 50.6
Total 172 172
Multiple CPO G 119 50.9 115 49.1 1.0 (0.8, 1.3) 0.7937
A 115 49.1 119 50.9
Total 234 234

1 GRR = genotype relative risk

2 CI = confidence interval

3 Significant values are marked in bold.

Minguzzi et al.

Minguzzi et al. BMC Medical Genetics 2012 13:29   doi:10.1186/1471-2350-13-29

Open Data