Open Access Research article

Mutations in the potassium channel subunit KCNE1 are associated with early-onset familial atrial fibrillation

Morten S Olesen1,2†, Bo H Bentzen1,3†, Jonas B Nielsen1,2, Annette B Steffensen1,3, Jens-Peter David1,3, Javad Jabbari1,2, Henrik K Jensen4, Stig Haunsø1,2,5, Jesper H Svendsen1,2,5 and Nicole Schmitt1,3*

1 The Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark

2 Laboratory for Molecular Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

3 The Ion Channel Group, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, 12.5.14, Copenhagen, N 2200, Denmark

4 Department of Cardiology, Aarhus University Hospital, Skejby, Denmark

5 Department of Surgery and Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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BMC Medical Genetics 2012, 13:24 doi:10.1186/1471-2350-13-24

Published: 3 April 2012

Additional files

Additional file 1:

The additional file (PDF) contains a detailed description of the methods, three additional figures (Additional file 1: Figure S1: Conservation of KCNE1 G25 and G60 within different species; Additional file 1: Figure S2: Comparison of IKs-WT and IKs-G25V channel currents in Xenopus laevis oocytes; Additional file 1: Figure S3: Comparison of IKs-WT and IKs-G60D and IKs-WT/G60D channel currents.), and additional references.

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