Open Access Highly Accessed Research article

Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL3

Madhushika Ratnayake1, Louise N Reynard1, Emma VA Raine1, Mauro Santibanez-Koref2 and John Loughlin1*

Author Affiliations

1 Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle, UK

2 Institute of Genetic Medicine, Newcastle University, Newcastle, UK

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BMC Medical Genetics 2012, 13:12  doi:10.1186/1471-2350-13-12

Published: 2 March 2012

Additional files

Additional file 1:

Real time reverse transcription assays for quantitative gene expression analysis.

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Additional file 2:

Linkage disequilibrium around BCL2L13, BID and MICAL3 showing the eight transcript SNPs and the associated SNP rs2277831.

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Additional file 3:

Primers and enzymes used for genotyping SNPs by RFLP analysis.

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Additional file 4:

Sequenom assays for allelic expression imbalance analysis.

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Additional file 5:

The Delta Ct values for the expression of BCL2L13, MICAL3 and BID in the cartilage of 32 OA patients.

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Open Data