Table 2

Association between SNPs and lung cancer
SNP PHWE Frequency of high-risk allele Observed OR, (95% CI)* P Genetic variance explained†
Rs2736100 0.49 0.41 1.18 (1.09-1.27) < 0.001 1.33%
Rs402710 0.43 0.68 1.10 (1.01-1.19) 0.034 0.40%
Rs1051730 0.05 0.02 1.09 (0.85-1.40) 0.108 -
Rs4083914 0.25 0.14 1.15 (1.03-1.28) 0.013 0.47%
Rs4488809 0.50 0.47 1.21 (1.11-1.30) < 0.001 1.82%

NOTE: CI, confidence interval; OR, odds ratio.

*Odds ratio per copy of the high-risk allele.

†The percentage of genetic variance was estimated under a liability threshold model: [2p (1-p)] β2 (p, risk allele frequency; β, additive allelic effect).

Li et al.

Li et al. BMC Medical Genetics 2012 13:118   doi:10.1186/1471-2350-13-118

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