Table 5

Comparison of the allele frequencies between the South Africans and other populations
SNP ID Minor allele South Africans this study (n=464) YRI HapMap (n=226) CEU HapMap (n=226) HCB HapMap (n=86) Bushman dbSNP (n=3)
NR1I2 rs3732356T>G G 0.234 0.254 0.033** N/A 0.000**
NR1I2 rs2472677C>T T 0.351 0.356 0.636** 0.544* N/A
NR1I2 rs6785049G>A A 0.040 0.000** 0.673** 0.453** N/A
NR1I3 rs2307424C>T T 0.047 0.119** 0.336** 0.512** N/A
NR1I3 rs3003596T>C C 0.416 0.612** 0.407 0.535 0.500
NR1I3 rs2502815C>T T 0.230 0.406** 0.248 0.442** 0.500**
n=32# n=226 n=226 n=86
NR1I2 rs12721601T>C C 0.016 0.008 N/A N/A N/A
NR1I2 rs59371185G>A A 0.016 0.000 N/A N/A N/A
NR1I2 rs12721613C>T T 0.064 0.183* 0.000* 0.000* N/A
NR1I2 rs1464603C>T T 0.016 N/A 0.292** 0.325** 0.000
NR1I2 rs1464602C>T T 0.313 0.186* 0.717** 0.675** 0.667**
NR1I2 rs80320762G>A A 0.048 0.144* N/A N/A N/A
NR1I2 rs12721616C>T T 0.219 0.042** N/A N/A N/A
NR1I2 rs112813596G>A A 0.016 N/A N/A N/A 0.000
NR1I3 rs35205211C>G G 0.032 N/A N/A N/A 0.005
NR1I3 rs34161743C>T T 0.016 N/A N/A N/A 0.005
NR1I2 36726T>C# C 0.078 N/A N/A N/A N/A
NR1I2 36857G>A# A 0.016 N/A N/A N/A N/A
NR1I2 36905C>T# T 0.031 N/A N/A N/A N/A

N/A = not available; *allele frequencies statistically significantly different from the South Africans (P<0.05), **allele frequencies statistically significantly different from the South Africans (P<0.001), #Sequencing according to the NR1I2 gene sequence [GenBank: AF364606] with the allele change for NR1I2 36857G>A according to the reverse sequence.

Swart et al.

Swart et al. BMC Medical Genetics 2012 13:112   doi:10.1186/1471-2350-13-112

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