Table 3

Studies of the rs1946518 and rs187238 polymorphisms in IL-18 gene and risk of RA and SLE under additive model grouped by study characteristics
Study characteristics Effect estimate of RA Effect estimate of SLE
Comparisons I2 OR (95% CI) Pvaluea Comparisons I2 OR (95% CI) Pvaluea
rs1946518 7 77.80% 0.752(0.562-1.006) 0.055 6 88.10% 0.684(0.455-1.028) 0.068
Population
 Chinese 4 52.90% 0.688(0.532-0.889) 0.004 5 87.00% 0.606(0.396-0.930) 0.022
 Other 3 40.10% 1.074(0.958-1.205) 0.702 1 NA 1.250(0.883-1.771) 0.208
Genotyping method
 PCR-SSP 5 36.50% 0.636(0.519-0.781) <0.001 2 96.70% 0.596(0.139-2.560) 0.487
 PCR–RFLP 1 NA 0.817(0.604-1.105) 0.189 3 74.60% 0.670(0.454-0.989) 0.044
 other 1 NA 1.088(0.969-1.222) 0.155 1 NA 0.945(0.686-1.303) 0.731
Sample size
 ≥300 3 50.60% 0.959(0.781-1.178) 0.693 3 76.80% 0.773(0.519-1.152) 0.207
 <300 4 0.00% 0.559(0.438-0.715) <0.001 3 93.50% 0.605(0.267-1.369) 0.228
HWE status
 Meeting HWE 6 81.30% 0.727(0.513-1.031) 0.073 6 88.10% 0.684(0.455-1.028) 0.068
 Deviating HWE 1 NA 0.857(0.590-1.244) 0.416 0 NA NA NA
rs187238 5 48.90% 1.296(0.959-1.751) 0.246 5 33.70% 1.166(0.948-1.435) 0.145
Population
 Chinese 3 70.30% 1.262(0.703-2.264) 0.436 4 45.60% 1.209(0.961-1.520) 0.105
 Other 2 0.00% 1.628(0.631-4.199) 0.314 1 NA 0.996(0.614-1.616) 0.986
Genotyping method
 PCR-SSP 5 48.90% 1.296(0.959-1.751) 0.246 3 0.00% 1.300(0.991-1.705) 0.416
 Other 0 NA NA NA 2 65.10% 0.987(0.570-1.710) 0.963
Sample size
 ≥150 3 70.30% 1.262(0.703-2.264) 0.436 2 0.00% 1.351(0.990-1.845) 0.058
 <150 2 0.00% 1.628(0.631-4.199) 0.314 3 54.70% 1.040(0.686-1.577) 0.854
HWE status
 Meeting HWE 5 48.90% 1.296(0.959-1.751) 0.246 4 34.20% 1.095(0.870-1.377) 0.439
 Deviating HWE 0 NA NA NA 1 NA 1.537(0.942-2.508) 0.085

a: p value of Z test NA: not available.

Chen et al.

Chen et al. BMC Medical Genetics 2012 13:107   doi:10.1186/1471-2350-13-107

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