Table 1

Characteristics of studies included in a meta-analysis of the IL-18 polymorphisms and rheumatoid arthritis and systemic lupus erythematosus
Disease Author(year) Country Population Sample size Polymorphisms evaluated Genotyping HWE in controls
(cases/controls) Pvalue
RA Sivalingam SP.2003 [23] Singapore Chinese 309(74/235) rs1946518 PCR-SSP <0.001
RA Sivalingam SP.2003 [23] Singapore Chinese 309(74/235) rs187238 PCR-SSP 0.442
RA Sivalingam SP.2003 [23] Singapore Indian 45(23/22) rs1946518 PCR-SSP 0.079
RA Sivalingam SP.2003 [23] Singapore Indian 45(23/22) rs187238 PCR-SSP 0.548
RA Sivalingam SP.2003 [23] Singapore Malay 25(9/16) rs1946518 PCR-SSP 0.605
RA Sivalingam SP.2003 [23] Singapore Malay 25(9/16) rs187238 PCR-SSP 0.904
RA Huang XZ.2007 [11] China Chinese 287(119/168) rs1946518 PCR-SSP 0.783
RA Huang XZ.2007 [11] China Chinese 288(120/168) rs187238 PCR-SSP 0.728
RA Sugiura T.2011 [25] Japan Japanese 2432(1462/970) rs1946518 TaqMan 0.052
RA Ying B.2011 [14] China Chinese 360(164/196) rs1946518 PCR–RFLP 0.543
RA Shi P.2011 [26] China Chinese 207(107/100) rs1946518 PCR-SSP 0.115
RA Shi P.2011 [26] China Chinese 207(107/100) rs187238 PCR-SSP 0.677
SLE Xu Q.2007 [12] Singapore Chinese 231(113/118) rs1946518 PCR–RFLP 0.050
SLE Xu Q.2007 [12] Singapore Chinese 231(113/118) rs187238 PCR-SSP 0.334
SLE Lin YJ.2007 [13] China(Taiwan) Chinese 301(160/141) rs1946518 Probe hybridization 0.088
SLE Lin YJ.2007 [13] China(Taiwan) Chinese 307(161/146) rs187238 Probe hybridization 0.290
SLE Lan Y.2008 [27] China Chinese 275(115/160) rs1946518 PCR–RFLP 0.606
SLE Lan Y.2008 [27] China Chinese 275(115/160) rs187238 PCR–RFLP 0.727
SLE Chen DY.2009 [28] China(Taiwan) Chinese 339(165/174) rs1946518 PCR–RFLP 0.130
SLE Hirankarn N.2009 [29] Thailand Thai 258(116/142) rs1946518 PCR-SSP 0.061
SLE Hirankarn N.2009 [29] Thailand Thai 258(116/142) rs187238 PCR-SSP 0.868
SLE Ye ZZ.2009 [24] China Chinese 289(165/124) rs1946518 PCR-SSP 0.549
SLE Ye ZZ.2009 [24] China Chinese 289(165/124) rs187238 PCR-SSP 0.030

Chen et al.

Chen et al. BMC Medical Genetics 2012 13:107   doi:10.1186/1471-2350-13-107

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