Table 2

Risk of dyspepsia according to 5-HTTLPR genotypes

FD, total (n = 53)

EPS (n = 39)1

PDS (n = 42)1




OR

(95%CI)

P

uncorrected (corrected)

OR

(95%CI)

P

uncorrected (corrected)

OR

(95%CI)

P

uncorrected (corrected)


5-HTTLPR genotype

SS

1

reference

1

reference

1

reference

SL

1.75

(0.96-3.19)

0.672

(1.000)

1.33

(0.65-2.73)

0.443

(0.886)

*2.24

(1.16-4.32)

0.017

(0.033)

LL

2.12

(0.59-7.59)

0.250

(0.499)

2.50

(0.69-9.10)

0.164

(0.328)

3.02

(0.83-11.06)

0.094

(0.188)

Recessive model

SS vs. SL+LL

1.79

(1.01-3.18)

0.472

1.46

(0.75-2.87)

0.268

*2.32

(1.23-4.37)

0.009


1Twenty eight subjects are simultaneously classified EPS and PDS phenotype.

FD, functional dyspepsia; EPS, epigastric pain syndrome; PDS, postprandial distress syndrome;

OR, sex- and age-adjusted odds ratio, vs. 646 controls, by a multiple logistic regression model; CI, confidence interval.

* Significant P < 0.05

Toyoshima et al. BMC Medical Genetics 2011 12:88   doi:10.1186/1471-2350-12-88

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