Table 1

Neovascular AMD Patient Clusters Defined by Phenotypic and Genotypic Risk Characteristics

Cluster % (N = 253)

Cluster 1

Cluster 2

Cluster 3

Cluster 4

F Statisti

P Value

n = 71

n = 84

n = 56

n = 42

c

28.1

33.2

22.1

16.6


Phenotypic Patient Characteristics


History of High Blood Pressure (%)

74.6

100.0

42.9

0.0

95.97

<.001


History of High Cholesterol (%)

100.0

45.2

1.8

28.6

89.68

<.001


BMI (± SD)

27.8 ± 4.7

26.4 ± 4.1

24.9 ± 4.5

26.8 ± 4.2

4.58

.004


Mean Age (± SD)

70.7 ± 8.4

74.5 ± 6.5

73.6 ± 6.9

73.9 ± 7.3

3.74

.012


Decades of Alcohol Consumption (± SD)

3.1 ± 2.2

3.2 ± 2.2

3.1 ± 2.2

3.8 ± 2.1

1.10

.351


Male Sex (%)

35.2

44.0

44.6

45.2

.605

.613


Mean Smoking in Total Pack Years (± SD)

25.4 ± 30.8

28.7 ± 31.4

25.3 ± 35.2

26.8 ± 33.4

.18

.910


Genotypic Patient Characteristics

HTRA1 rs1049331


TT* (%)

52.1

0.0

83.9

0.0

101.28

<.001


CC (%)

5.6

56.0

3.6

59.5

39.60

<.001


TC (%)

42.3

44.0

12.5

40.5

6.12

<.001


CFH rs1061170 (Y402H)


TT (%)

31.0

0.0

35.7

0.0

20.68

<.001


CC* (%)

32.4

41.7

21.4

57.1

5.06

.002


CT (%)

36.6

58.3

42.9

42.9

2.72

.045


*Risk alleles within each genotype

Feehan et al. BMC Medical Genetics 2011 12:83   doi:10.1186/1471-2350-12-83

Open Data