Table 5

Potential transcription factor binding sites within the PRDX6 gene

SNP

Location

Base Change

Reference Sequence

Alternative Sequence


PRDX6_171709541

5' UTR

G/C

n/a

Sp1, CACCC binding factor, PuF


rs13376447

5' UTR

A/G

GATA-1

GATA-1


PRDX6_171709910

5' UTR

G/T

n/a

IL-6 RE-BP


rs10753081

5' UTR

C/T

GATA-3

GATA-1


PRDX6_171710327

5' UTR

C/T

C/EBPbeta

C/EBPbeta


PRDX6_171710775

5' UTR

G/C

c-Myb

n/a


rs9425722

5' UTR

C/T

n/a

c-Myc


rs35152701

5' UTR

A/G

n/a

TMF, TBP, TFIID


rs12739142

5' UTR

A/G

IPF1, Isl-1, IPF1

IPF1


rs4354572

5' UTR

C/T

C/EBPbeta

AFP1, ATBF1-B


rs11576174

5' UTR

G/T

H4TF-1

ETF, TMF, TFIID, TBP


PRDX6_171712345

5' UTR

A/T

n/a

SRY, TCF-4E


PRDX6_171712345

5' UTR

A/T

n/a

SRY


rs35441546

5' UTR

C/T

Sp1, ETF

CACCC-binding factor, Sp1


rs35133735

5' UTR

C/T

n/a

CACCC-binding factor, Sp1


rs6671141

intron

G/T

GR alpha, PR, PR A, GR beta

n/a


PRDX6_171713738

intron

G/T

n/a

TEF-1


PRDX6_171713872

intron

C/T

n/a

H4TF-1


rs35918328

intron

A/G

IPF1

n/a


rs33942654

intron

A/G

c-Myb

n/a


PRDX6_171714984

intron

C/T

TBP

GATA-1


PRDX6_171715019

intron

A/G

GATA-3

GATA-1


rs9425723

intron

A/G

TBP, TFIID

AP-1, c-Jun


rs9425724

intron

A/G

USF1

AP-1, AP-4, CCK-1a, c-Myc, CREB, Max1, USF1


PRDX6_171715596

intron

A/G

c-Myb, c-Ets-2

n/a


PRDX6_171716007

intron

A/G

n/a

Sp1, C/EBPbeta, CACCC-binding factor


PRDX6_171716572

intron

A/T

TMF, TFIID, ETF, TBP

n/a


PRDX6_171716582

intron

A/G

GATA-1, GATA-3

n/a


PRDX6_171716584

intron

A/T

GATA-1, GATA-3

SRY


*Transcription factor binding site modeling was performed using TESS.

Rushefski et al. BMC Medical Genetics 2011 12:77   doi:10.1186/1471-2350-12-77

Open Data