Figure 2.

Distribution of FST. A. Distribution of FST of 158 SNPs associated with cardiovascular diseases and related intermediate traits. The vertical bar shows the mean of global FST of these 158 SNPs (FST = 0.1042). B. Distribution of empirical global mean FST of 158 autosomal SNPs randomly sampled from HGDP database 1000 times. The distribution of minor allele frequency of the randomly selected 158 SNPs was matched to the observed 158 SNPs. The vertical bar shows the mean of global FST of 158 SNPs associated with cardiovascular diseases and related intermediate traits (FST = 0.1042). C. Distribution of empirical global FST of 2,036 markers assumed to be neutral, genotyped in 938 unrelated individuals form HGDP. Two vertical lines indicate 95% and 99% percentile of the global FST distribution. The vertical bars show the values of global FST value of 158 susceptibility SNPs in the present study.

Ding and Kullo BMC Medical Genetics 2011 12:55   doi:10.1186/1471-2350-12-55
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