Open Access Highly Accessed Research article

Geographic differences in allele frequencies of susceptibility SNPs for cardiovascular disease

Keyue Ding and Iftikhar J Kullo*

Author Affiliations

Division of Cardiovascular Diseases, Mayo Clinic, Rochester MN 55905, USA

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BMC Medical Genetics 2011, 12:55  doi:10.1186/1471-2350-12-55

Published: 20 April 2011

Additional files

Additional file 1:

Supplementary methods. The supplementary methods describe 1) selection of cardiovascular disease phenotypes and related quantitative traits; and 2) calculation of geographic distance in kilometers for each pair of populations.

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Additional file 2:

Table S1. Sample size in the HGDP populations.

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Additional file 3:

Table S2. A list of SNPs associated with cardiovascular diseases/traits identified in genome-wide association studies.

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Additional file 4:

Table S3. The number of risk alleles with various categories of RAF differences: comparisons of a given geographic area versus the rest of the world.

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Additional file 5:

Table S4. A list of SNPs with significantly higher global FST (Pcor < 0.05)

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Additional file 6:

Figure S1. Pairwise comparison of population differentiation for SNPs with a significantly higher global FST among 52 populations. The shaded boxes in the matrices indicate the significance level of FST based on the empirical distribution of the 2,036 SNPs for each pair of populations. The inserted subplot shows the comparison for the seven populations based on the geographic areas.

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Additional file 7:

Figure S2. Number of SNPs that showed a significantly higher FST in pairwise comparisons among the seven geographic areas.

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Additional file 8:

Figure S3. Multidimensional scaling analysis plot (dimension I/II) of 938 individuals from seven geographic areas using 158 SNPs sampled from the HGDP database. Description: The population 'Mozabite' (black circle) was clustered into the 'Middle East', and 'Europe', which was geographically located in North Africa. The populations in 'Central_South_Asia' showed a cline from 'Middle East' and 'Europe' to 'East_Asia'. Different colors and point characters indicate seven geographic areas (see figure legend).

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Additional file 9:

Table S5. Analysis of molecular variance (AMOVA) of 158 SNPs.

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