Table 3

APOE Genotype and APOE allele frequency by dementia status, with crude and adjusted prevalence ratios and 95% confidence intervals

Dementia

N(%) 273

No dementia

N(%) 2247

Whole sample

N(%) 2520

Crude PR

(95%CI)

Adjusted1 PR

(95%CI)


APOE genotype

e2/e3

24

(8.8%)

255

(11.4%)

279

(11.1%)

0.97 (0.64-1.46)

0.96 (0.64-1.44)

e2/e4

2

(0.7%)

15

(0.7%)

17

(0.7%)

1.33 (0.36-4.91)

1.42 (0.37-5.45)

e3/e3

162

(59.3%)

1663

(74.0%)

1825

(72.4%)

1.00 (ref.)

1.00 (ref.)

e3/e4

77

(28.2%)

285

(12.7%)

362

(14.4%)

2.40 (1.88-3.06)

2.59 (2.04-3.28)

e4/e4

8

(2.9%)

29

(1.3%)

37

(1.5%)

2.44 (1.30-4.57)

2.88 (1.58-5.27)

p-value (Test for heterogeneity)

X2 = 54.6, 4 df p < 0.001

X2 = 46.6, 4 df p < 0.001

Number of APOE e4 alleles

0

186

(68.1%)

1918

(85.4%)

2104

(83.5%)

1.00 (ref.)

1.00 (ref.)

1

79

(28.9%)

300

(13.4%)

379

(15.0%)

2.36 (1.86-2.99)

2.55 (2.02-3.21)

2

8

(2.9%)

29

(1.3%)

37

(1.5%)

2.45 (1.31-4.58)

2.90 (1.59-5.29)

p-value (Test for trend)

X2 = 55.5, 1 df p < 0.001

X2 = 41.8, 1 df p < 0.001

Any APOE e4 allele

1 or 2 alleles

87

(31.9%)

329

(14.6%)

416

(16.5%)

2.37 (1.88-2.98)

2.58 (2.06-3.22)

p-value

X2 = 53.0, 1 df p < 0.001

X2 = 45.6, 1 df p < 0.001

APOE allele frequency

e2

0.048

0.060

0.059

e3

0.778

0.860

0.851

e4

0.174

0.080

0.090


p-value (Test for trend)

X2 = 61.7, 1 df, P < 0.001


1 Adjusted for age, sex and education - X2 derived from likelihood ratio tests

Teruel et al. BMC Medical Genetics 2011 12:43   doi:10.1186/1471-2350-12-43

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