Table 6

Fetal and maternal haplotypes in COL5A2

Fetal haplotypes

Maternal haplotypes

Combined

markers

haplotype

freq

RR

95% CI

p

RR

95% CI

p

Overall p


rs6760780-rs3923384-rs6434317

T-A-C

0.830

1.00

-

-

1.00

-

-

0.013

T-A-A

0.091

0.65

0.41, 1.05

0.077

1.20

0.77, 1.86

0.419

A-G-A

0.041

1.82

1.06, 3.08

0.030

0.78

0.44, 1.41

0.413

A-A-A

0.037

0.33

0.14, 0.81

0.014

1.48

0.76, 2.88

0.244

rs3923384-rs6434317-rs6434322

A-C-G

0.828

1.00

-

-

1.00

-

-

0.006

A-A-G

0.129

0.54

0.36, 0.82

0.004

1.26

0.87, 1.84

0.241

G-A-A

0.042

1.81

1.06, 3.10

0.029

0.78

0.43, 1.39

0.393

rs6434317-rs6434322-rs10165260

C-G-A

0.829

1.00

-

-

1.00

-

-

0.006

A-G-A

0.129

0.55

0.36, 0.83

0.006

1.27

0.88, 1.84

0.210

A-A-G

0.042

1.81

1.06, 3.10

0.026

0.77

0.43, 1.40

0.385

rs6434322-rs10165260-rs7420331

G-A-A

0.829

1.00

-

-

1.00

-

-

0.006

G-A-G

0.129

0.54

0.36, 0.82

0.004

1.26

0.87, 1.83

0.232

A-G-A

0.042

1.80

1.06, 3.11

0.026

0.78

0.43, 1.39

0.392

rs10165260-rs7420331-rs13024858

A-A-A

0.792

1.00

-

-

1.00

-

-

0.041

A-G-A

0.109

0.58

0.37, 0.91

0.018

1.33

0.90, 1.97

0.159

A-A-C

0.035

1.46

0.78, 2.76

0.242

0.70

0.35, 1.44

0.329

G-A-A

0.022

2.23

1.12, 4.57

0.023

0.63

0.28, 1.40

0.262

A-G-C

0.020

0.38

0.10, 1.55

0.175

0.72

0.23, 2.29

0.582

G-A-C

0.019

1.44

0.65, 3.20

0.362

0.95

0.42, 2.23

0.901

rs7420331-rs13024858-rs6752781

A-A-A

0.817

1.00

-

-

1.00

-

-

0.043

G-A-A

0.109

0.55

0.35, 0.86

0.009

1.37

0.92, 2.05

0.116

A-C-G

0.053

1.41

0.86, 2.38

0.187

0.83

0.48, 1.42

0.516

G-C-G

0.020

0.47

0.13, 1.81

0.277

0.70

0.22, 2.22

0.542


Hybrid analysis

1 Calculation of haplotypes has been performed in Haplin with a sliding window of three SNPs.

2 Haplotypes are not adjusted for multiple testing.

Myking et al. BMC Medical Genetics 2011 12:174   doi:10.1186/1471-2350-12-174

Open Data