Table 5

Fetal and maternal haplotypes in COL5A2

Fetal haplotypes

Maternal haplotypes

Combined

Markers

Haplotype

freq

RR

95% CI

p

RR

95% CI

p

Overall p


rs6760780-rs3923384-rs6434317

T-A-C

0.810

1.00

-

-

1.00

-

-

0.006

T-A-A

0.116

0.55

0.33, 0.92

0.021

0.97

0.59, 1.60

0.920

A-A-A

0.035

0.33

0.13, 0.85

0.020

1.50

0.64, 3.50

0.351

A-G-A1

0.034

2.11

1.05, 4.22

0.035

0.84

0.44, 1.60

0.594

rs3923384-rs6434317-rs6434322

A-C-G

0.810

1.00

-

-

1.00

-

-

0.003

A-A-G1

0.154

0.49

0.31, 0.77

0.002

1.08

0.70, 1.67

0.724

G-A-A

0.034

2.09

1.03, 4.19

0.042

0.83

0.44, 1.60

0.588

rs6434317-rs6434322-rs10165260

C-G-A

0.810

1.00

-

-

1.00

-

-

0.003

A-G-A1

0.154

0.49

0.31, 0.76

0.002

1.07

0.69, 1.65

0.747

A-A-G

0.034

2.09

1.03, 4.18

0.040

0.83

0.43, 1.60

0.584

rs6434322-rs10165260-rs7420331

G-A-A

0.810

1.00

-

-

1.00

-

-

0.003

G-A-G

0.154

0.49

0.31, 0.77

0.001

1.08

0.70, 1.67

0.726

A-G-A

0.035

2.09

1.03, 4.19

0.041

0.83

0.44, 1.61

0.592

rs10165260-rs7420331-rs13024858

A-A-A

0.762

1.00

-

-

1.00

-

-

0.010

A-G-A

0.149

0.50

0.31, 0.79

0.003

1.00

0.64, 1.58

0.993

A-A-C

0.047

1.20

0.58, 2.44

0.631

0.57

0.27, 1.20

0.138

G-A-A

0.028

1.74

0.72, 4,24

0.211

0.50

0.21, 1.19

0.122

G-A-C

0.008

2.37

0.71, 7.54

0.151

1.70

0.56, 5.11

0.343

rs7420331-rs13024858-rs6752781

A-A-A

0.794

1.00

-

-

1.00

-

-

0.016

C-A-A

0.151

0.48

0.30, 0.77

0.002

1.03

0.65, 1.60

0.913

A-C-G

0.053

1.43

0.77, 2.63

0.259

0.81

0.44, 1.48

0.492


Case-parent triad analysis

1 Haplotype deviates from Hardy-Weinberg equilibrium.

2 Calculation of haplotypes has been performed in Haplin with a sliding window of three SNPs.

3 Haplotypes are not adjusted for multiple testing.

Myking et al. BMC Medical Genetics 2011 12:174   doi:10.1186/1471-2350-12-174

Open Data