Table 4

Significant SNPs in COL5A2 (collagen V alpha-2) and COL5A1 (collagen V alpha-1)

Fetal

Maternal

Combined

gene

snp

allele

MAF

RR

95% CI

p

RR

95% CI

p

overall p


COL5A2

rs3923384

G

0.042

1.95

1.14,3.31

0.015

0.76

0.42, 1.35

0.347

0.055

rs6434322

A

0.042

1.94

1.14,3.31

0.013

0.76

0.42, 1.35

0.342

0.055

rs10165260

G

0.042

1.95

1.14,3.31

0.015

0.76

0.42, 1.35

0.347

0.055

rs7420331

G

0.129

0.53

0.35,0.81

0.004

1.28

0.87, 1.85

0.199

0.008

COL5A1

rs3124311

C

0.510

0.77

0.60, 0.99

0.045

1.06

0.83, 1.37

0.624

0.130

rs4842157

G

0.364

0.75

0.57, 0.99

0.039

1.07

0.81, 1.39

0.631

0.115

rs4842161

C

0.458

1.40

1.10, 1.80

0.008

0.81

0.63, 1.03

0.085

0.017

rs3124932

A

0.433

1.52

1.19, 1.96

0.0004

0.78

0.61, 1.00

0.054

0.002

rs12005720

G

0.161

0.74

0.53, 1.04

0.090

1.40

1.01, 1.94

0.043

0.063

rs3128621

A

0.441

1.48

1.16, 1.90

0.001

0.70

0.54, 0.90

0.006

0.001

rs4842167

G

0.424

1.37

1.07, 1.76

0.014

0.64

0.49, 0.82

0.001

0.001

rs3811161

G

0.465

0.78

0.61, 1.00

0.055

1.49

1.16, 1.90

0.003

0.004

rs3811152

G

0.103

0.55

0.35, 0.86

0.009

1.54

1.04, 2.27

0.033

0.009

rs10745387

A

0.434

1.25

0.98, 1,61

0.073

0.70

0.54, 0.90

0.005

0.011


Hybrid analysis

1 Results are not corrected for multiple testing.

2 A multiplicative model is assumed.

Myking et al. BMC Medical Genetics 2011 12:174   doi:10.1186/1471-2350-12-174

Open Data