Table 3

Significant SNPs in COL5A2 (collagen V alpha-2) and COL5A1 (collagen V alpha-1)

Fetal

Maternal

Combined

gene

snp

allele

MAF

RR

95% CI

p

RR

95% CI

p

overall p


COL5A2

rs3923384

G

0.034

2.29

1.12, 4.54

0.021

0.83

0.43, 1.59

0.568

0.048

rs6434322

A

0.034

2.29

1.12, 4.54

0.021

0.83

0.43, 1.59

0.568

0.048

rs10165260

G

0.034

2.29

1.12, 4.54

0.021

0.83

0.43, 1.59

0.568

0.048

rs7420331

G

0.154

0.47

0.30, 0.73

0.001

1.09

0.70, 1.69

0.710

0.003

COL5A1

rs4842161

C

0.482

1.32

0.99, 1.75

0.060

0.75

0.57, 1.00

0.055

0.024

rs3124932

A

0.433

1.53

1.14, 2.03

0.005

0.78

0.58, 1.04

0.084

0.003

rs12005720

G

0.137

0.83

0.56, 1.22

0.343

1.61

1.08, 2.40

0.018

0.034

rs3128621

A

0.440

1.49

1.12, 1.99

0.008

0.70

0.53, 0.93

0.015

0.001

rs4842167

G

0.388

1.51

1.13, 2.03

0.007

0.70

0.52, 0.93

0.016

0.001

rs3811161

G

0.509

0.70

0.52, 0.93

0.012

1.32

0.99, 1.75

0.060

0.007

rs3811152

G

0.092

0.59

0.36, 0.95

0.032

1.72

1.05, 2.79

0.031

0.008

rs10745387

A

0.405

1.36

1.02, 1.82

0.037

0.75

0.56, 1.00

0.055

0.016


Case-parent triad analysis

1 Results are not corrected for multiple testing.

2 A multiplicative model is assumed.

Myking et al. BMC Medical Genetics 2011 12:174   doi:10.1186/1471-2350-12-174

Open Data