Research article
The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers
1 Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Queen's Medical Centre, Nottingham, UK
2 Sheffield Institute for Studies on Ageing, University of Sheffield, Barnsley Hospital NHSFT, Barnsley, UK
3 National Heart and Lung Institute, Imperial College London, London, UK
4 Institute for Lung Health and Department of Infection, Immunity and Inflammation, Glenfield Hospital, University of Leicester, Leicester, UK
5 Freemasons' Department of Geriatric Medicine, University of Auckland, Auckland
BMC Medical Genetics 2011, 12:173 doi:10.1186/1471-2350-12-173
Published: 29 December 2011Additional files
Additional file 1:
Baseline lung function (FEV1 and FEV1/FVC ratio) and ALOX5AP, LTA4H and LTB4R SNPs in the smokers (n = 992). This table shows the results of the association analysis between leukotriene pathway SNPs and baseline FEV1 and FEV1/FVC using the additive model. Covariates included in the model were age, gender, height and pack years. Associations with p < 0.05 are shown in bold black.
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