Table 2

Top Candidate SNPs from the Ashkenazi Jewish, NINDS and CIDR/Pankratz et al 2009 Datasets

Ashkenazi Jewish

NINDS

CIDR/Pankratz et al 2009

Meta-analysis


SNP

CHR

BP

A1

GENE

F_A

P

OR

F_A

P

OR

F_A

P

OR

A2

Z

P

Direction


F_U

95% CI

F_U

95% CI

F_U

95% CI

score


rs1694037

3

21941114

T

LOC10055836

0.096

1.02 × 10-5

0.42

0.097

0.849

1.02

0.121

0.049

1.24

T

-1.3

0.193

- ++

0.199

0.29-0.62

0.095

0.81-1.28

0.100

1.00-1.54


rs4976493

5

135210022

A

SLC25A48

0.442

6.66 × 10-5

1.77

0.403

0.026

1.17

0.367

0.190

0.91

A

2.8

0.005

++-

0.309

1.34-2.35

0.366

1.02-1.34

0.389

0.79-1.05


rs10121009

9

35259819

A

UNC13B

0.131

5.32 × 10-5

0.49

0.182

0.045

0.84

0.185

0.032

0.83

A

-4.7

2.75 × 10-6

- - -

0.235

0.34-0.69

0.209

0.71-1.00

0.214

0.70-0.98


rs4745122*

9

73582507

A

Intergenic

0.351

5.48 × 10-5

1.87

0.243

0.007

1.25

0.234

0.748

0.97

A

3.7

2.15 × 10-4

++-

0.225

1.38-2.54

0.205

1.06-1.47

0.239

0.83-1.14


rs7171137

15

90363631

A

SLCO3A1

0.397

3.79 × 10-5

1.84

0.370

0.013

1.20

0.351

0.620

1.04

A

4.1

4.09 × 10-5

+++

0.264

1.38-2.47

0.330

1.04-1.38

0.343

0.90-1.19


rs183211

17

42143493

T

NSF

0.207

7.16 × 10-5

0.54

0.213

0.102

0.87

0.196

0.001

0.77

T

-5.1

2.80 × 10-7

- - -

0.326

0.40-0.73

0.236

0.75-1.03

0.241

0.65-0.90


rs415430

17

42214305

C

WNT3

0.202

8.45 × 10-5

0.54

0.173

0.002

0.77

C

-5.0

6.87 × 10-7

--

--

0.317

0.40-0.74

0.214

0.65-0.91


A1: Minor allele, A2: Associated allele, F_A: Minor allele freq. of case, F_U: Minor allele freq. of control, OR: odds ratios, 95% CI: 95% confidence interval, * rs4745122 is located ~8.9Kb proximal to TMEM2.

Liu et al. BMC Medical Genetics 2011 12:104   doi:10.1186/1471-2350-12-104

Open Data