Open Access Highly Accessed Research article

Genome-Wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population

Xinmin Liu1, Rong Cheng2, Miguel Verbitsky1, Sergey Kisselev3, Andrew Browne3, Helen Mejia-Sanatana2, Elan D Louis1245, Lucien J Cote2, Howard Andrews6, Cheryl Waters4, Blair Ford4, Steven Frucht1, Stanley Fahn1, Karen Marder1247, Lorraine N Clark138* and Joseph H Lee1258

Author Affiliations

1 Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA

2 Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA

3 Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY, USA

4 Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA

5 Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA

6 New York State Psychiatric Institute, Data Coordinating Center, New York, NY, USA

7 Department of Psychiatry, Columbia University Medical Center, NYC, NY, USA

8 Center for Human Genetics, College of Physicians and Surgeons, Columbia University, New York, NY, USA

For all author emails, please log on.

BMC Medical Genetics 2011, 12:104  doi:10.1186/1471-2350-12-104

Published: 3 August 2011

Additional files

Additional file 1:

'Top' 57 SNPs with P value < 9.9 × 10-5 identified in the Ashkenazi Jewish PD GWAS. 'Top' 57 SNPs with P value < 9.9 × 10-5 identified in the Ashkenazi Jewish PD GWAS. OR: odds ratios, 95% CI: 95% confidence interval.

Format: DOC Size: 148KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 2:

SNPs reaching Genome Wide Significance in the NINDS and CIDR/Pankratz et al 2009 datasets. SNPs reaching Genome Wide Significance in the NINDS and CIDR/Pankratz et al 2009 datasets. OR: odds ratios, 95% CI: 95% confidence interval.

Format: DOC Size: 70KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 3:

Haplotype analysis of LOC15328/SLC25A48, UNC13B, SLCO3A1, WNT3 in 2 or 3 datasets. a). Haplotype analysis of LOC15328/SLC25A48 in 3 datasets. These haplotype results in Additional file 3 a), b), c) and d) are further evaluation of the SNPs in Table 2. *SNP 1, rs2304075; 2, rs6596270; 3, rs4976493; 4, rs4246802; 5, rs7717673. b) Haplotype analysis of UNC13B in 3 datasets. *SNP 1, rs7036061; 2, rs7040048; 3, rs10121009; 4, rs10114937; 5, rs10758303. c) Haplotype analysis of SLCO3A1 in 3 datasets. *SNP 1, rs1400784; 2, rs2387400; 3, rs7171137; 4, rs12913189; 5, rs6496888. d) Haplotype analysis of WNT3 in Ashkenazi Jewish and NINDS. *SNP 1, rs12325819; 2, rs199533; 3, rs415430; 4, rs2074404; 5, rs199494; rs415430 is not on the CIDR/Pankratz et al 2009 dataset.

Format: DOC Size: 308KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 4:

Single SNP association of the genes reported in other studies: GBA, BST1, SNCA, HLA-DRA and LRRK2. Single SNP association of the genes reported in other studies: GBA, BST1, SNCA, HLA-DRA and LRRK2. F_A: Minor allele freq. of case, F_U: Minor allele freq. of control, OR: odds ratios, 95% CI: 95% confidence interval.

Format: DOC Size: 210KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 5:

Single SNP association of the genes reported by the International Parkinson Disease Genomics Consortium: STK39, MCCC1 and LAMP3. Single SNP association of the genes reported by the International Parkinson Disease Genomics Consortium: STK39, MCCC1 and LAMP3. OR: odds ratios, 95% CI: 95% confidence interval

Format: DOC Size: 83KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data