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Testing the thrifty gene hypothesis: the Gly482Ser variant in PPARGC1A is associated with BMI in Tongans

Sean Myles123*, Rod A Lea4, Jun Ohashi5, Geoff K Chambers6, Joerg G Weiss3, Emilie Hardouin127, Johannes Engelken117, Donia P Macartney-Coxson4, David A Eccles6, Izumi Naka5, Ryosuke Kimura8, Tsukasa Inaoka9, Yasuhiro Matsumura10 and Mark Stoneking7

Author Affiliations

1 Institute for Genomic Diversity, Cornell University, Ithaca, NY, USA

2 Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY, USA

3 Department of Biology, Acadia University, Wolfville, Canada

4 Institute of Environmental Science and Research Ltd, Porirua, New Zealand

5 Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan

6 School of Biological Sciences, Victoria University of Wellington, New Zealand

7 Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany

8 Transdisciplinary Research Organization for Subtropical and Island Studies (TRO-SIS), University of the Ryukyus, Okinawa, Japan

9 Department of Human Ecology, Faculty of Agriculture, Saga University, Saga, Japan

10 Faculty of Health Care, Kiryu University, Gunma, Japan

11 Institute of Evolutionary Biology, Pompeu Fabra University, Barcelona, Spain

12 Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Plön, Germany

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BMC Medical Genetics 2011, 12:10  doi:10.1186/1471-2350-12-10

Published: 18 January 2011

Additional files

Additional file 1:

Table S1: Summary of the Gly482Ser genotype data used in the present study. The geographic origin, genotype frequencies, allele frequencies and the P values from a test of Hardy-Weinberg equilibrium are presented for each of the populations genotyped for the Gly482Ser SNP in the present study.

Format: XLS Size: 27KB Download file

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