Table 3

The association between rs702553 at the PDE4D gene and carotid atherosclerosis

Atherosclerotic risk

Overall

Men

Women


AA + AT

TT

statistics

AA + AT

TT

statistics

AA + AT

TT

statistics


Carotid plaque

N = 544

N = 108

N = 216

N = 40

N = 328

N = 68

No plaque (index = 0)

354 (83.7%)

69 (16.3%)

ref.

129 (86.6%)

20 (13.4%)

ref.

225 (82.1%)

49 (17.9%)

ref.

Low-risk (index = 1-3)

163 (84.5%)

30 (15.5%)

OR = 1.0 (0.6-1.7) p = 0.934

66 (84.6%)

12 (15.4%)

OR = 1.5 (0.7-3.6) p = 0.312

97 (84.3%)

18 (15.7%)

OR = 0.8 (0.4-1.5) P = 0.534

High-risk (index ≥ 4)

27 (75.0%)

9 (25.0%)

OR = 3.1 (1.1-8.7) p = 0.034

21 (72.4%)

8 (27.6%)

OR = 5.9 (1.6-21.5) p = 0.008

6 (85.7%)

1 (14.3%)

OR = NA


Age-adjusted IMT(mm)

N = 775

N = 162

N = 367

N = 76

N = 408

N = 86

CCA

0.61 ± 0.12

0.62 ± 0.11

p = 0.150

0.63 ± 0.14

0.66 ± 0.13

p = 0.041

0.59 ± 0.10

0.59 ± 0.08

p = 0.862

Bif

0.65 ± 0.12

0.66 ± 0.13

p = 0. 396

0.67 ± 0.12

0.70 ± 0.14

p = 0.068

0.63 ± 0.11

0.62 ± 0.09

p = 0.472

ICA

0.51 ± 0.10

0.51 ± 0.11

p = 0.518

0.53 ± 0.11

0.55 ± 0.13

p = 0.111

0.48 ± 0.08

0.48 ± 0.08

p = 0.441

Dichotomized IMT (advanced atherosclerotic group(> mean + 1SD)

CCA

98 (12.7%)

23 (14.5%),

OR = 1.2 (0.7-1.9) p = 0.584

43 (11.7%)

17(22.4%)

OR = 2.1 (1.1-4.1) p = 0.032

55 (13.5%)

6 (7.2%)

OR = 0.5 (0.2-1.2) p = 0.109

Bif

110 (14.2%)

30 (18.9%),

OR = 1.5 (0.9-2.3) p = 0.099

53 (14.5%)

17 (22.4%)

OR = 1.8 (0.9-3.3) p = 0.078

57 (14.0%)

13 (15.7%)

OR = 1.1 (0.6-2.2) p = 0.686

ICA

96 (12.5%)

20 (12.7%),

OR = 1.0 (0.6-1.7) p = 0.940

36 (9.9%)

7 (9.2%)

OR = 0.8 (0.3-1.9) p = 0.588

60 (14.8%)

13 (16.0%)

OR = 1.1 (0.6-2.2) p = 0.724


OR (95% confidence interval) was obtained from logistic regression with adjustment of age, hypertension, diabetes, hyperlipidemia and smoking.

Age-adjusted IMT was presented as mean ± SD

Liao et al. BMC Medical Genetics 2010 11:93   doi:10.1186/1471-2350-11-93

Open Data