Table 3 

The association between rs702553 at the PDE4D gene and carotid atherosclerosis 

Atherosclerotic risk 
Overall 
Men 
Women 



AA + AT 
TT 
statistics 
AA + AT 
TT 
statistics 
AA + AT 
TT 
statistics 



Carotid plaque 
N = 544 
N = 108 
N = 216 
N = 40 
N = 328 
N = 68 

No plaque (index = 0) 
354 (83.7%) 
69 (16.3%) 
ref. 
129 (86.6%) 
20 (13.4%) 
ref. 
225 (82.1%) 
49 (17.9%) 
ref. 
Lowrisk (index = 13) 
163 (84.5%) 
30 (15.5%) 
OR = 1.0 (0.61.7) p = 0.934 
66 (84.6%) 
12 (15.4%) 
OR = 1.5 (0.73.6) p = 0.312 
97 (84.3%) 
18 (15.7%) 
OR = 0.8 (0.41.5) P = 0.534 
Highrisk (index ≥ 4) 
27 (75.0%) 
9 (25.0%) 
OR = 3.1 (1.18.7) p = 0.034 
21 (72.4%) 
8 (27.6%) 
OR = 5.9 (1.621.5) p = 0.008 
6 (85.7%) 
1 (14.3%) 
OR = NA 


Ageadjusted IMT(mm) 
N = 775 
N = 162 
N = 367 
N = 76 
N = 408 
N = 86 

CCA 
0.61 ± 0.12 
0.62 ± 0.11 
p = 0.150 
0.63 ± 0.14 
0.66 ± 0.13 
p = 0.041 
0.59 ± 0.10 
0.59 ± 0.08 
p = 0.862 
Bif 
0.65 ± 0.12 
0.66 ± 0.13 
p = 0. 396 
0.67 ± 0.12 
0.70 ± 0.14 
p = 0.068 
0.63 ± 0.11 
0.62 ± 0.09 
p = 0.472 
ICA 
0.51 ± 0.10 
0.51 ± 0.11 
p = 0.518 
0.53 ± 0.11 
0.55 ± 0.13 
p = 0.111 
0.48 ± 0.08 
0.48 ± 0.08 
p = 0.441 
Dichotomized IMT (advanced atherosclerotic group(> mean + 1SD) 

CCA 
98 (12.7%) 
23 (14.5%), 
OR = 1.2 (0.71.9) p = 0.584 
43 (11.7%) 
17(22.4%) 
OR = 2.1 (1.14.1) p = 0.032 
55 (13.5%) 
6 (7.2%) 
OR = 0.5 (0.21.2) p = 0.109 
Bif 
110 (14.2%) 
30 (18.9%), 
OR = 1.5 (0.92.3) p = 0.099 
53 (14.5%) 
17 (22.4%) 
OR = 1.8 (0.93.3) p = 0.078 
57 (14.0%) 
13 (15.7%) 
OR = 1.1 (0.62.2) p = 0.686 
ICA 
96 (12.5%) 
20 (12.7%), 
OR = 1.0 (0.61.7) p = 0.940 
36 (9.9%) 
7 (9.2%) 
OR = 0.8 (0.31.9) p = 0.588 
60 (14.8%) 
13 (16.0%) 
OR = 1.1 (0.62.2) p = 0.724 


OR (95% confidence interval) was obtained from logistic regression with adjustment of age, hypertension, diabetes, hyperlipidemia and smoking. Ageadjusted IMT was presented as mean ± SD 

Liao et al. BMC Medical Genetics 2010 11:93 doi:10.1186/147123501193 