Allelic variants of IL1R1 gene associate with severe hand osteoarthritis
- Equal contributors
1 Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland
2 Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland
3 Department of Public Health, University of Helsinki, Helsinki, Finland
4 ORTON Orthopedic Hospital, Invalid Foundation, Helsinki, Finland
5 Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada
6 Department of Mental Health, National Institute for Health and Welfare, Helsinki, Finland
7 Wellcome Trust Sanger Institute, Cambridge, United Kingdom
8 The Broad Institute of MIT and Harvard, Boston, MA, USA
9 Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland
10 Department of Medical Genetics, University of Helsinki, Helsinki, Finland
BMC Medical Genetics 2010, 11:50 doi:10.1186/1471-2350-11-50Published: 30 March 2010
In search for genes predisposing to osteoarthritis (OA), several genome wide scans have provided evidence for linkage on 2q. In this study we targeted a 470 kb region on 2q11.2 presenting the locus with most evidence for linkage to severe OA of distal interphalangeal joints (DIP) in our genome wide scan families.
We genotyped 32 single nucleotide polymorphisms (SNPs) in this 470 kb region comprising six genes belonging to the interleukin 1 superfamily and monitored for association with individual SNPs and SNP haplotypes among severe familial hand OA cases (material extended from our previous linkage study; n = 134), unrelated end-stage bilateral primary knee OA cases (n = 113), and population based controls (n = 436).
Four SNPs in the IL1R1 gene, mapping to a 125 kb LD block, provided evidence for association with hand OA in family-based and case-control analysis, the strongest association being with SNP rs2287047 (p-value = 0.0009).
This study demonstrates an association between severe hand OA and IL1R1 gene. This gene represents a highly relevant biological candidate since it encodes protein that is a known modulator of inflammatory processes associated with joint destruction and resides within a locus providing consistent evidence for linkage to hand OA. As the observed association did not fully explain the linkage obtained in the previous study, it is plausible that also other variants in this genome region predispose to hand OA.